Cytochalasin D

Cytochalasin D
Other names Zygosporin A; Cytohalasin D; Lygosporin A
Identifiers
CAS number	22144-77-0
PubChem	5458428
ChemSpider	16736231 Y
Jmol-3D images	Image 1 Image 2
SMILES C[C@H]1C/C=C/[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C/[C@@](C1=O)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O CC(=O)OC4/C=C/C(C)(O)C(=O)C(C)C\C=C/C2C(O)C(=C)C(C)C3C(Cc1ccccc1)NC(=O)C234
InChI InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14+ Y Key: SDZRWUKZFQQKKV-JIIHXHDGSA-N Y InChI=1/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14+ Key: SDZRWUKZFQQKKV-JIIHXHDGBR
Properties
Molecular formula	C30H37NO6
Molar mass	507.62 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cytochalasin D is a member of the class of mycotoxins known as cytochalasins. Cytochalasin D is an alkaloid produced by Helminthosporium and other molds.

Cytochalasin D is a cell permeable and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It is believed to bind to G actin and prevent polymerization of actin monomers. ^[1]

References

1. ^ Heptinstall, J. A. May H. Ratan J. R. Glenn W. L (1998). "GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly.". Platelets 9 (3): 227–32. doi:10.1080/09537109876744. PMID 16793707. 

External links

• MeSH Cytochalasin+D

This article about an organic compound is a stub. You can help Wikipedia by expanding it.v · Categories: Organic compound stubs Mycotoxins Actin inhibitors Acetate esters Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат James P. Stark Ladd Army Airfield Look at other dictionaries: Cytochalasin B — Other names Phomin Identifiers …   Wikipedia Cytochalasin E — Cytochalasin E[1] Identifiers CAS number …   Wikipedia cytochalasin B — cytochalasin B. См. цитохалазин В. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь. cytochalasin B — cytochalasin used to examine the role of microfilaments in the morphology and physiology of cells; it causes microfilaments to disappear by inhibiting the assembly of actin filaments, thus blocking numerous cell processes, e.g., cytokinesis,… …   Medical dictionary Cytochalasin — Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology,… …   Wikipedia Cytochalasin — Cy|to|cha|la|sin [↑ cyto griech. chálasis = Erschlaffung], das; s, e: Sammelbez. aus Schimmelpilzkulturen für isolierte ↑ Mykotoxine, die inhibitorisch auf versch. Zellfunktionen wirken. Die C. sind tricycl. Makrolide mit einem 11 bis 14… …   Universal-Lexikon cytochalasin — noun Etymology: cyt + Greek chalasis slackening + English 1 in Date: 1966 any of a group of metabolites isolated from fungi (especially Helminthosporium dematioideum) that inhibit various cell processes …   New Collegiate Dictionary cytochalasin — noun Any of several related fungal metabolites that have an effect on cytokinesis while not affecting karyokinesis …   Wiktionary cytochalasin — cy·to·cha·la·sin .sīt ō kə lā sən n any of a group of metabolites isolated from fungi (esp. Helminthosporium dematioideum) that inhibit various cell processes * * * cy·to·chal·a·sin (si″to kalґə sin) any of a group of fungal… …   Medical dictionary cytochalasin — n. type of metabolite derived from fungi (used to hinder production of microfilaments and thereby stops cellular processes that depend upon microfilaments) …   English contemporary dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”