Cytochalasin E

Cytochalasin E[1]
Identifiers
CAS number	36011-19-5
PubChem	5458385
EC number	252-835-7
Jmol-3D images	Image 1
SMILES C[C@H]1C/C=C/[C@H]2[C@H]3[C@](O3)([C@H]([C@@H]4[C@]2(C(=O)N[C@H]4CC5=CC=CC=C5)OC(=O)O/C=C/[C@@](C1=O)(C)O)C)C
Properties
Molecular formula	C28H33NO7
Molar mass	495.56 g mol−1
Hazards
EU classification	T+
R-phrases	R26/27/28 R63
S-phrases	S28 S36/37 S45
Main hazards	Toxic
Y E (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cytochalasin E, a member of the cytochalasin group, is an inhibitor of actin polymerization in blood platelets. It inhibits angiogenesis and tumor growth. Unlike cytochalasin A and cytochalasin B, it does not inhibit glucose transport.

Because of its antiangiogenic effect, cytochalasin E is a potential drug for age-related macular degeneration, a kind of blindness caused by an abnormal proliferation of blood vessels in the eye.^[2]

References

1. ^ Cytochalasin E from Aspergillus clavatus at Sigma-Aldrich
2. ^ eyesight.org

External pages

Cytochalasin E from Fermentek