Chemical compound microarray

A chemical compound microarray is a collection of organic chemical compounds spotted on a solid surface, such as glass and plastic. This microarray format is very similar to DNA microarray, protein microarray and antibody microarray. In chemical genetics research, they are routinely used for searching proteins that bind with specific chemical compounds, and in general drug discovery research, they provide a multiplex way to search potential drugs for therapeutic targets.

There are three different forms of chemical compound microarrays based on the fabrication method. The first form is to covalently immobilize the organic compounds on the solid surface with diverse linking techniques; this platform is usually called Small Molecule Microarray, which is invented and advanced by Dr. Stuart Schreiber and colleagues[1]. The second form is to spot and dry organic compounds on the solid surface without immobilization, this platform has a commercial name as Micro Arrayed Compound Screening (µARCS), which is developed by scientists in Abbott Laboratories [2]. The last form is to spot organic compounds in a homogenous solution without immobilization and drying effect, this platform is developed by Dr. Scott Diamond [3] and later commercialized as DiscoveryDot technology by Reaction Biology Corporation [4].

Polymer Microarrays

Polymer microarrays have been developed to allow screening for new polymeric materials to direct different tissue lineages. Research has also been directed towards studying the surface chemistry of these arrays to determine which surface chemistries control cell adhesion.

DiscoveryDot Microarray for Kinase Profiling

References

• Uttamchandani, M. et al. (2005) "Small molecule microarrays, recent advances and applications". Curr Opin Chem Biol. 9, 4–13 [5].
• Walsh, D.P. and Chang, Y.T. (2004) "Recent Advances in Small Molecule Microarrays, Applications and Technology". Comb Chem High Throughput Screen. 7, 557–564 [6].
• Hoever, M. and Zbinden, P. (2004) "The evolution of microarrayed compound screening. Drug Discov". Today 9, 358–365.
• Gosalia, DN and Diamond, SL. (2003) "Printing Chemical libraries on microarrays for fluid phase nanoliter reactions". Proc. Natl. Acad. Sci. USA, 100, 8721–8726 [7].
• Ma, H. et al. (2005) "Nanoliter Homogenous Ultra High Throughput Screening Microarray for Lead Discoveries and IC50 Profiling". Assay Drug Dev. Technol. 3, 177–187 [8].
• Horiuchi, K.Y. et al. (2005) "Microarrays for the functional analysis of the chemical-kinase interactome", accepted, J Biomol Screen. 11, 48–56 [9].
• Ma, H. and Horiuchi, K.Y. (2006) "Chemical Microarray: a new tool for drug screening and discovery", Drug Discovery Today, 11, 661–668 [10].

This nanotechnology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Nanotechnology Microarrays Nanotechnology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Free Software Initiative of Japan Broadway at Iroquois Look at other dictionaries: Microarray — A microarray is a multiplex lab on a chip. It is a 2D array on a solid substrate (usually a glass slide or silicon thin film cell) that assays large amounts of biological material using high throughput screening methods. Types of microarrays… …   Wikipedia Protein microarray — A protein microarray, sometimes referred to as a protein binding microarray, is a piece of glass on which different molecules of protein have been affixed at separate locations in an ordered manner thus forming a microscopic array. These are used …   Wikipedia Chemical biology — is a scientific discipline spanning the fields of chemistry and biology that involves the application of chemical techniques and tools, often compounds produced through synthetic chemistry, to the study and manipulation of biological systems.… …   Wikipedia Antibody microarray — An antibody microarray is a specific form of protein microarrays, a collection of capture antibodies are spotted and fixed on a solid surface, such as glass, plastic and silicon chip for the purpose of detecting antigens. Antibody microarray is… …   Wikipedia DNA-encoded chemical library — DNA encoded chemical libraries (DEL) are a new technology for the synthesis and screening of collections of chemical compounds of unprecedented size and quality. DEL represents an advance in medicinal chemistry which bridges the fields of… …   Wikipedia Biochip — The development of biochips is a major thrust of the rapidly growing biotechnology industry, which encompasses a very diverse range ofresearch efforts including genomics, proteomics, computational biology, and pharmaceuticals, among other… …   Wikipedia MAGIChip — MAGIChips, also known as Microarrays of Gel immobilized Compounds on a chip or Three dimensional DNA Microarrays are devices for molecular hybridization produced by immobilizing oligonucleotides, DNA, enzymes, antibodies, and other compounds on a …   Wikipedia Multiplex (assay) — For other uses of multiplex, see multiplex (disambiguation). A multiplex assay is a type of laboratory procedure that simultaneously measures multiple analytes (dozens or more) in a single assay. It is distinguished from procedures that measure… …   Wikipedia Small molecule — In pharmacology, a small molecule is a small organic compound that is biologically active (biomolecule) but is not a polymer. This term is very loosely used and it may or may not include monomers or primary metabolites, in fact it is generally… …   Wikipedia Glass transition — The liquid glass transition (or glass transition for short) is the reversible transition in amorphous materials (or in amorphous regions within semicrystalline materials) from a hard and relatively brittle state into a molten or rubber like state …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”