Cyclopiazonic acid

Cyclopiazonic acid
Cyclopiazonic acid
Identifiers
CAS number 18172-33-3 N
PubChem 65261
ChemSpider 21106432 YesY
ChEBI CHEBI:22450 YesY
ChEMBL CHEMBL480627 YesY
Jmol-3D images Image 1
Properties
Molecular formula C20H20N2O3
Molar mass 336.38 g mol−1
 N acid (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cyclopiazonic acid (CPA) is a toxic fungal secondary metabolite. Chemically, it is an indole tetramic acid.

CPA was originally isolated from Penicillium cyclopium and subsequently from other P. cyclopium, Penicillium griseofulvum, Penicillium camembertii, Aspergillus flavus and Aspergillus versicolor.

Cyclopiazonic acid only appears to be toxic in high concentrations.

Biologically, Cyclopiazonic acid is a specific inhibitor of Ca2+-ATPase in the intracellular Ca2+ storage sites.


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