Aristolochic acid

Aristolochic acid
Aristolochic acid
CAS number 313-67-7
PubChem 2236
ChemSpider 2149 YesY
KEGG C08469 YesY
Jmol-3D images Image 1
Molecular formula C17H11NO7
Molar mass 341.27 g mol−1
Density 1.571g/cm3
Melting point

260 - 265 °C

Boiling point

615.5°C @760mmHg

Solubility in water slightly soluble in water
Flash point 326°C
 YesY acid (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic compounds commonly found in the Aristolochiaceae family of plants, including Aristolochia and Asarum, which are commonly used in Chinese herbal medicine.[1] Aristolochic acid I is the most abundant of the aristolochic acids and is found in almost all Aristolochia species.[2] Aristolochic acids are often accompanied by aristolactams.[3]

Aristolochic acids may be a causative agent in Balkan nephropathy.[4][5] Exposure to aristolochic acid is associated with a high incidence of uroepithelial tumorigenesis.[6]

Aristolochic acids are slightly soluble in water, have a melting point between 281 and 286 degrees celsius,[7] and have a bitter flavor.[8]


See also


  1. ^ Nolin, Thomas D. & Himmelfarb, Jonathan (2010). "Mechanisms of drug-induced nephrotoxicity". In Uetrecht, Jack. Adverse Drug Reactions. Springer. p. 123. ISBN 9783642006623. 
  2. ^ Wu, Tian-Shung et al. (2005). "Chemical constituents and pharmacology of Aristolochia species". In Rahman, Atta-ur. Studies in Natural Products Chemistry: Bioactive Natural Products (Part L). Gulf Professional Publishing. p. 863. ISBN 9780444521712. 
  3. ^ Wink, Michael & Schimmer, Oskar (1999). "Modes of action of defensive secondary metabolites". In Wink, Michael. Functions of plant secondary metabolites and their exploitation in biotechnology. CRC Press. p. 75. ISBN 9780849340864. 
  4. ^ Geacintov, Nicholas E. & Broyde, Suse, ed (2010). "Introduction and perspectives on the Chemistry and Biology of DNA Damage". The Chemical Biology of DNA Damage. Wiley-VCH. p. 7. ISBN 9783527322954. 
  5. ^ Wild, Chris et al., ed (2008). Molecular epidemiology of chronic diseases. John Wiley & Sons. p. 113. ISBN 9780470027431. 
  6. ^ Ronco, Claudio et al., ed (2008). Critical care nephrology. Elsevier Health Sciences. p. 1699. ISBN 9781416042525. 
  7. ^ Barceloux, Donald G. (2008). "Aristolochic acid and Chinese Herb nephropathy". Medical toxicology of natural substances: foods, fungi, medicinal herbs, plants, and venomous animals. John Wiley & Sons. p. 384. ISBN 9780471727613. 
  8. ^ Offermanns, S. & Amara, Susan G., ed (2006). Reviews of physiology, biochemistry and pharmacology, Volume 154. Birkhäuser. p. 56. ISBN 9783540303848. 

Further reading

  • Aronson, J.K. (2008). "Aristolochicae". Meyler's side effects of herbal medicines. Elsevier. p. 55. ISBN 9780444532695. 
  • Lai M., 2009. Journal of National Cancer Institute. doi:10.1093/jnci/djp467. (Short summary published as "Chinese herbal products containing aristolochic acid were associated with urinary tract cancer" in "HemOnc today", page 28, dated 2010-01-25.)
  • Mills, Simon & Bone, Kerry (2005). "Aristolochic Acid Nephropathy". The essential guide to herbal safety. Elsevier Health Sciences. p. 15. ISBN 9780443071713. 
  • Wing-Tat Poon, Chi-Kong Lai, Albert Yan-Wo Chan, 2007. "Aristolochic Acid Nephropathy: The Hong Kong Perspective." Hong Kong Journal of Nephrology, 9(1):7-14.

External links

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Look at other dictionaries:

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  • Asarum — taxobox name = Asarum image caption = Wild ginger leaves ( Asarum caudatum ) regnum = Plantae unranked divisio = Angiosperms unranked classis = Magnoliids ordo = Piperales familia = Aristolochiaceae genus = Asarum subdivision ranks = Species… …   Wikipedia

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