duodenal ulcer.
Ulcers are healing wounds that develop on the skin, mucous membranes, or eye. Although they have many causes, they are marked by:
# Loss of integrity of the area
# Secondary infection of the site by bacteria, fungus or virus
# Generalized weakness of the patient
# Delayed healing


The word ulcer is first attested from ca. 1400 CE, deriving from Old French "ulcere", which came from Latin "ulcus" "ulcer", ultimately from the Proto-Indo-European base *elk-es- "wound". [ [http://www.etymonline.com/index.php?term=ulcer Online Etymology Dictionary's entry on "ulcer".] ]

kin ulcer classification schemes

The skin is the largest organ of the human body. Classification systems are used to communicate the severity and depth of an ulcer. It is an easy way to communicate changes for the better, or worse.

Raghavendra manual classification

* Stage 1: The skin is red. The underlying tissue is soft. The redness disappears with minor pressure.
* Stage 2: There is redness, swelling and hardening of the skin around the area. Sometimes there is blistering. Sometimes there is loss of the superficial skin.
* Stage 3: The skin becomes necrotic. There may be exposure of the fat beneath the skin. The skin may be lost through all its layers.
* Stage 4: There is more loss of fat and more necrosis of the skin through to the muscle beneath.
* Stage 5: Continuing loss of fat and necrosis of muscle below.
* Stage 6: Bone destruction begins with irritation of the bone, erosion of the bone cortex progressing to osteomyelitis. There may be sepsis of a joint, pathologic fracture or generalized body infection, septicemia.

This staging system for rating ulcers, is designed to rate the severity of pressure ulcers.
* Stage 1: There is erythema of intact skin which does not blanch with pressure. It may be the heralding lesion of skin ulceration.
* Stage 2: There is partial skin loss involving the epidermis, dermis, or both. The ulcer is superficial and presents as an abrasion, blister, or wound with a shallow center.
* Stage 3: This is an entire thickness skin loss. It may involve damage to or necrosis of subcutaneous tissue that may extend down to, but not through, the underlying fascia. The ulcer presents as a deep crater with or without undermining of adjacent intact tissues.
* Stage 4: Here there is entire thickness skin loss with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures. Tendons, and joints may also be exposed or involved. There may be undermining and/or sinus tracts associated with ulcers at this stage.

University of Texas Health Science Center Classification

This classification system is intended to rate the severity of diabetic foot ulcerations.

* Grade 0: Skin with prior healed ulcer scars, areas of pressure which are sometimes called pre-ulcerative lesion or the presence of bony deformity which puts pressure on an unguarded point.
* Grade 1-A: The wound is superficial in nature, with partial or full-thickness skin involvement but does not include tendon, capsule or bone.
* Grade 1-B: As above, the wound is superficial in nature, with partial or full thickness skin involvement but not including tendon, capsule nor bone; however the wound is infected. The definition of this wound implies superficial infection without involvement of underlying structures. If the wound shows signs of significant purulence or fluctuation, further exploration to expose a higher grade classification of infection is in order.
* Grade 1-C: As above but with vascular compromise.
* Grade 1-D: As above but ischemic. Because ischemia is a type of vascular compromise, the distinction between these two grades is often difficult to make.
* Grade 2-A: Penetration through the subcutaneous tissue exposing tendon or ligament, but not bone.
* Grade 2-B: Penetration through the deep tissues including tendon or ligament and even joint capsule but not bone.
* Grade 2-C: As above 2B, but including ischemic.
* Grade 2-D: As above 2C, but including infection.
* Grade 3-A: A wound which probes to bone but shows no signs of local infection nor systemic infection.
* Grade 3-B: A wound which probes to bone and is infected.
* Grade 3-C: A wound which probes to bone, is infected, and is ischemic.
* Grade 3-D: A wound which probes to bone characterized by active infection, ischemic tissues, and exposed bone.
* Grade 4: Gangrene of the forefoot.
* Grade 5: Gangrene of the entire foot.

Other locations

# Inferior members: most ulcers of the foot and leg are caused by underlying vascular insufficiency. The skin breaks down or fails to heal because of repeated trauma. Pressure of the nail can cause subungual ulceration. These are most frequently seen in diabetics who have a very low potential to heal from injury.

# Sacrum and ischium
# Mouth ulcer
# Peptic ulcers: This includes ulcers of the esophagus, stomach, large and small intestine
# Genitalia: May be penile, vulvar or labial. Most often are due to sexually transmitted diseases
# Eyes: corneal ulcers are the most common type. Conjunctival ulcers also occur.

Pathology of ulceration


The most common causes (not in order) are:
* Bacterial infection
* Viral infection
* Fungal infection
* Cancer - both 'primary' and 'secondary'
* Venous stasis
* Arterial Insufficiency
* Diabetes
* Rheumatoid Arthritis
* Amyloidosis
* Loss of mobility
* Hypertension
* Gastroesophageal reflux disease


Some specific types of ulcers are:
*Peptic ulcer (of the stomach, esophageal cardium or duodenum)
*Mouth ulcer
*Pressure ulcer (decubitus)
*Crural ulcer (due to venous insufficiency or other causes)
*Hunner's ulcer (of the bladder caused by Interstitial Cystitis)
*Ulcerative colitis (of the colon)
*Curling's ulcer
*Cushing ulcer
*Arterial insufficiency ulcer
*Venous insufficiency ulcer
*Diabetic foot ulcer
*Corneal ulcer
*Vascular ulcer


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Look at other dictionaries:

  • ulcer — ÚLCER, ulcere, s.n. 1. Leziune (fără tendinţă de cicatrizare) care apare pe suprafaţa pielii sau a mucoaselor (stomacului, duodenului); boală caracterizată prin prezenţa unor astfel de leziuni; ulcus (1). 2. Boală a arborilor, pricinuită de… …   Dicționar Român

  • Ulcer — Ul cer, n. [F. ulc[ e]re, L. ulcus, gen. ulceris, akin to Gr. ?.] 1. (Med.) A solution of continuity in any of the soft parts of the body, discharging purulent matter, found on a surface, especially one of the natural surfaces of the body, and… …   The Collaborative International Dictionary of English

  • ulcer — (n.) c.1400, from O.Fr. ulcere, from V.L. ulcerem, from L. ulcus (gen. ulceris) ulcer, from PIE *elk es wound (Cf. Gk. elkos) …   Etymology dictionary

  • ulcer — [ul′sər] n. [L ulcus (gen. ulceris) < IE * elkos , abscess > Sans árśas , hemorrhoids, Gr helkos, abscess, wound] 1. an open sore (other than a wound) on the skin or some mucous membrane, as the lining of the stomach (peptic ulcer),… …   English World dictionary

  • Ulcer — Ul cer, v. t. To ulcerate. [R.] Fuller. [1913 Webster] …   The Collaborative International Dictionary of English

  • ulcer — ► NOUN ▪ an open sore on the body, caused by a break in the skin or mucous membrane which fails to heal. DERIVATIVES ulcered adjective ulcerous adjective. ORIGIN Latin ulcus …   English terms dictionary

  • ulcer — /ul seuhr/, n. 1. Pathol. a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue, the formation of pus, etc. 2. See peptic ulcer. 3. any chronically corrupting or disrupting condition, element, etc. [1350 1400; ME …   Universalium

  • Ulcer — An area of tissue erosion, for example, of the skin or lining of the gastrointestinal (GI) tract. Due to the erosion, an ulcer is concave. It is always depressed below the level of the surrounding tissue. Ulcers can have diverse causes. Ulcers on …   Medical dictionary

  • ulcer — n. 1) a break in an epithelial surface. 2) a break in the skin extending to all its layers, or a break in the mucous membrane lining the alimentary tract, that fails to heal and is often accompanied by inflammation. Of the many types of skin… …   The new mediacal dictionary

  • ulcer — Synonyms and related words: abdominal hernia, abscess, aposteme, bane, bed sore, blain, bleb, blight, blister, boil, bubo, bulla, bunion, cancer, canker, canker sore, carbuncle, chancre, chancroid, chilblain, cold sore, colitis, curse, disease,… …   Moby Thesaurus

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