Richard Deth

Richard Deth
Richard Deth
Born	November 3, 1945 (1945-23-03) (age 65)
Occupation	Professor of Pharmacology, Northeastern University
Spouse	Maddy Deth
Website
http://www.northeastern.edu/bouve/faculty/deth_r.html

Richard Deth, Ph.D., is a neuropharmacologist, a professor of pharmacology at Northeastern University in Boston, Massachusetts, and is on the scientific advisory board of the National Autism Association. Deth has published scientific studies on the role of D4 dopamine receptors in psychiatric disorders, as well as the book, Molecular Origins of Human Attention: The Dopamine-Folate Connection. He has also become a prominent voice in the controversies in autism and vaccine controversy, due to his hypothesis that certain children are more at risk than others because they lack the normal ability to excrete neurotoxic metals.

Research focus

The primary realm of research conducted by Deth involves the role of D4 dopamine receptors in schizophrenia and attention. He has focused on understanding the molecular basis of transmembrane signaling by G protein-coupled receptors, the study of their structure using three-dimensional molecular graphics, and modeling how the binding of various drugs causes a shift in their molecular form.^[1]

Deth has characterized the conformation-dependent participation of D4 dopamine receptors in the process of phospholipid methylation, and found that different states of methylation yield varying degrees of spontaneous activity of G protein coupling. He has theorized that these processes are involved in the neural mechanisms of attention.^[2] Deth has found that insulin-like growth factor-1 (IGF-1) and dopamine both stimulated folate-dependent methylation pathways in neuronal cells, while compounds like ethanol, the vaccine preservative thimerosal, and metals (like mercury, which is contained in thimerosal, and lead) inhibited these same biochemical pathways at low concentrations resembling those found following vaccination or other sources of exposure. An enzyme mediating methylation, methionine synthase, uses an active form of vitamin B₁₂ to complete its chemical function. Thimerosal interferes with the conversion of dietary forms of B₁₂ into the active form and so impedes DNA methylation and disrupts mercury detoxification and some normal gene actions.^[3]

Based on this research, Deth has theorized that thimerosal in vaccines could give rise to autism in a subset of children who are genetically vulnerable. He has played an active role in the thimerosal controversy, testifying twice to Congress about his views. Deth's hypothesis is, however, contradicted by much of the current literature about the causes of autism, which indicates that the levels of thimerosal found in vaccines and other sources cannot be directly implicated as a cause.^[4][5]

See also

• List of vaccine-related topics

References

1. ^ Zhu Q., Qi, L-J., Abou-Samra, A., Shi, A. and Deth, R.C.: "Protein kinase C-dependent constitutive activity of a2A/D-adrenergic receptors." Pharmacol. 71: 80-90 (2004).
2. ^ Deth, R.C. "Molecular Origins of Attention: The Dopamine-Folate Connection" Kluwer Academic Publishers (2003).
3. ^ Waly, M., Banerjee, R., Choi, S.W., Mason, J., Benzecry, J., Power-Charnitsky, V.A, Deth, R.C. "PI3-kinase regulates methionine synthase: Activation by IGF-1 or dopamine and inhibition by heavy metals and thimerosal" Molecular Psychiatry 9: 358-370 (2004).
4. ^ Doja A, Roberts W (2006). "Immunizations and autism: a review of the literature". Can J Neurol Sci 33 (4): 341–6.
5. ^ Taylor B (2006). "Vaccines and the changing epidemiology of autism". Child Care Health Dev 32 (5): 511–9.

External links

• NEU.edu - Richard Deth (homepage), Northeastern University

Persondata
Name	Deth, Richard
Alternative names
Short description
Date of birth	1945
Place of birth
Date of death
Place of death