Chrysiasis

Chrysiasis
Chrysiasis
Classification and external resources
ICD-10 L81.8 (ILDS L81.856)

Chrysiasis (Gk, chrysos-gold, osis-condition of) is a dermatological condition induced by the parenteral administration of gold salts, usually for the treatment of rheumatoid arthritis.[1]:859-60 Such treatment has been superseded as the best practice for treating the disease because of "numerous side effects and monitoring requirments [sic], their limited efficacy, and very slow onset of action".[2]

Similar to silver, a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation - especially if the skin is exposed to sunlight or artificial ultraviolet radiation.

The skin's pigmentation (in this condition) has been described as uniformly gray, grayish purple, slate gray, or grayish blue, and is usually limited to exposed portions of the body. It may involve the conjunctivae over the scleras but usually not the oral mucosa. Location of pigment predominantly in the upper dermis leads to the blue component of skin color through the scattering phenomenon. It is much less likely to be deposited in the nails and hair.

Chrysiasis was said to have been much more common when medicines containing traces of gold were used for treatment of tuberculosis (commonplace forms of treatment nearly fifty years ago). Treatments containing gold traces were also used to treat cases of rheumatoid arthritis - but because the dose used for tuberculosis was higher than for arthritis, it has not afflicted many subscribing to such treatments.

Gold can be identified in the skin chemically by light microscopy, electron microscopy, and spectroscopy.

There is no way to reverse, or treatment for, chrysiasis.

See also

Notes

  1. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ^ http://www.hopkins-arthritis.org/arthritis-info/rheumatoid-arthritis/rheum_treat.html#gold

References

  • Jeghers - New England Journal of Medicine, Vol. 231: 122 & 181, 1944
  • Scamberg - "Chrysoderma - A permanent gold staining of the skin". Archives of Dermatology & Syphilis, Vol. 18. 862, 1928
  • The University of Massachusetts Online Article on Skin Pigmentation Disorders [1]
v · d · ePigmentation disorders/Dyschromia (L80–L81, 709.0)
Hypo-/
leucism
Loss of melanocytes

vitiligo: Quadrichrome vitiligo · Vitiligo ponctué · syndromic (Alezzandrini syndrome · Vogt–Koyanagi–Harada syndrome)

melanocyte development: Piebaldism · Waardenburg syndrome · Tietz syndrome
Loss of melanin/
amelanism

albinism: Oculocutaneous albinism · Ocular albinism

melanosome transfer: Hermansky–Pudlak syndrome · Chédiak–Higashi syndrome · Griscelli syndrome (Elejalde syndrome · Griscelli syndrome type 2 · Griscelli syndrome type 3)

other: Cross syndrome · ABCD syndrome · Albinism–deafness syndrome · Idiopathic guttate hypomelanosis · Phylloid hypomelanosis · Progressive macular hypomelanosis
Leukoderma w/o
hypomelanosis
Vasospastic macule · Woronoff's ring · Nevus anemicus
Ungrouped
ungrouped: Nevus depigmentosus · Postinflammatory hypopigmentation · Pityriasis alba · Vagabond's leukomelanoderma · Yemenite deaf-blind hypopigmentation syndrome · Wende–Bauckus syndrome
Hyper-
Reticulated
Dermatopathia pigmentosa reticularis · Pigmentatio reticularis faciei et colli · Reticulate acropigmentation of Kitamura · Reticular pigmented anomaly of the flexures · Naegeli–Franceschetti–Jadassohn syndrome · Dyskeratosis congenita · X-linked reticulate pigmentary disorder · Galli–Galli disease · Revesz syndrome
Diffuse/
circumscribed

Lentigo/Lentiginosis: Lentigo simplex · Liver spot · Centrofacial lentiginosis · Generalized lentiginosis · Inherited patterned lentiginosis in black persons · Ink spot lentigo · Lentigo maligna · Mucosal lentigines · Partial unilateral lentiginosis · PUVA lentigines

Melasma · Erythema dyschromicum perstans · Lichen planus pigmentosus · Café au lait spot · Poikiloderma (Poikiloderma of Civatte · Poikiloderma vasculare atrophicans) · Riehl melanosis
Linear
Other/ungrouped
Acanthosis nigricans (Acral acanthotic anomaly) · Freckle · Familial progressive hyperpigmentation · Pallister–Killian syndrome · Periorbital hyperpigmentation · Photoleukomelanodermatitis of Kobori · Postinflammatory hyperpigmentation · Transient neonatal pustular melanosis
Other
pigments
iron: Hemochromatosis · Iron metallic discoloration · Pigmented purpuric dermatosis (Schamberg disease, Majocchi's disease, Gougerot–Blum syndrome, Doucas and Kapetanakis pigmented purpura/Eczematid-like purpura of Doucas and Kapetanakis, Lichen aureus, Angioma serpiginosum) · Hemosiderin hyperpigmentation
other metals: Argyria · Chrysiasis · Arsenic poisoning · Lead poisoning · Titanium metallic discoloration
Dyschromatoses
Dyschromatosis symmetrica hereditaria · Dyschromatosis universalis hereditaria

M: INT, SF, LCT

anat/phys/devp

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

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Look at other dictionaries:

  • chrysiasis — A permanent slate gray discoloration of the skin and sclera resulting from deposition of gold in macrophages. SYN: auriasis, aurochromoderma. [G. chrysos, gold] * * * chry·si·a·sis krə sī ə səs n, pl a·ses .sēz an ash gray or mauve pigmentation… …   Medical dictionary

  • Chrysiasis — Chry|si|a|sis, die; , ...siases [...ze:s] u. ...siasen: ↑Chrysose …   Universal-Lexikon

  • Chrysiasis — Chrysi̱a|sis [zu gr. χρυσος = Gold] w; , ...si̱a|ses od. ...sia̱|sen, auch …   Das Wörterbuch medizinischer Fachausdrücke

  • Chrysiasis — Chry|si|a|sis die; , ...iasen <zu ↑...iasis> svw. ↑Chrysose …   Das große Fremdwörterbuch

  • chrysiasis — n. the deposition of gold in the eye and other tissues as a result of prolonged or excessive treatment with gold salts …   The new mediacal dictionary

  • хризиаз почек — (chrysiasis renum; греч. chrysos золото + иаз) поражение почек токсико аллергической, реже токсической природы, возникающее при поступлении в организм солей золота, характеризующееся их накоплением в ткани почек; проявляется нефротическим… …   Большой медицинский словарь

  • Хризиа́з по́чек — (chrysiasis renum; греч. chrysos золото + иаз) поражение почек токсико аллергической, реже токсической природы, возникающее при поступлении в организм солей золота, характеризующееся их накоплением в ткани почек; проявляется нефротическим… …   Медицинская энциклопедия

  • auriasis — SYN: chrysiasis. * * * au·ri·a·sis (aw riґə sis) chrysiasis (def. 1) …   Medical dictionary

  • List of cutaneous conditions — This is an incomplete list, which may never be able to satisfy particular standards for completeness. You can help by expanding it with reliably sourced entries. See also: Cutaneous conditions, Category:Cutaneous conditions, and ICD 10… …   Wikipedia

  • Albinism — Albino redirects here. For other uses, see Albino (disambiguation). Albinism Classification and external resources A black child with albinism ICD 10 …   Wikipedia

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