NINL

Ninein-like
Identifiers
Symbols	NINL; FLJ11792; KIAA0980; NLP; dJ691N24.1
External IDs	OMIM: 609580 MGI: 1925427 HomoloGene: 57024 GeneCards: NINL Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • cytoplasm • microtubule organizing center • cytosol • cytoskeleton • microtubule Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22981	78177
Ensembl	ENSG00000101004	ENSMUSG00000068115
UniProt	Q9Y2I6	Q6ZQ12
RefSeq (mRNA)	NM_025176	NM_207204.2
RefSeq (protein)	NP_079452	NP_997087.2
Location (UCSC)	Chr 20: 25.43 – 25.57 Mb	Chr 2: 150.76 – 150.87 Mb
PubMed search	[1]	[2]

Ninein-like protein is a protein that in humans is encoded by the NINL gene.^[1][2] It is part of the centrosome^[3].

References

1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
2. ^ "Entrez Gene: RP4-691N24.1 KIAA0980 protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22981. 
3. ^ Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (Ph.D thesis). http://edoc.ub.uni-muenchen.de/1962/1/Casenghi_Martina.pdf. 

Further reading

• Wang Y, Zhan Q (2007). "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex.". J. Biol. Chem. 282 (24): 17712–9. doi:10.1074/jbc.M701350200. PMID 17403670. 
• Casenghi M, Barr FA, Nigg EA (2005). "Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.". J. Cell. Sci. 118 (Pt 21): 5101–8. doi:10.1242/jcs.02622. PMID 16254247. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.". Dev. Cell 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.