CEP250

Centrosomal protein 250kDa, also known as CEP250, is a human gene.cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternately spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Faragher AJ, Fry AM |title=Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2876–89 |year= 2004 |pmid= 12857871 |doi= 10.1091/mbc.E03-02-0108
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mayor T, Hacker U, Stierhof YD, Nigg EA |title=The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. |journal=J. Cell. Sci. |volume=115 |issue= Pt 16 |pages= 3275–84 |year= 2003 |pmid= 12140259 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Mayor T, Stierhof YD, Tanaka K, "et al." |title=The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |doi=
*cite journal | author=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875–83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200
*cite journal | author=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509–18 |year= 2001 |pmid= 10880350 |doi=
*cite journal | author=Fry AM, Mayor T, Meraldi P, "et al." |title=C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1563–74 |year= 1998 |pmid= 9647649 |doi=
*cite journal | author=Mack GJ, Rees J, Sandblom O, "et al." |title=Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. |journal=Arthritis Rheum. |volume=41 |issue= 3 |pages= 551–8 |year= 1998 |pmid= 9506584 |doi= 10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X |doilabel=10.1002/1529-0131(199803)41:3551::AID-ART223.0.CO;2-X

PBB_Controls
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