NBPF10

Neuroblastoma breakpoint family member
Identifiers
Symbols	LOC100288142; AB6; AG1; DKFZp564A057; DKFZp586O031; DKFZp686C1532; FLJ20719; FLJ43804; LOC100132406; MGC182975
External IDs	OMIM: 610414 HomoloGene: 41035 GeneCards: LOC100288142 Gene
Gene Ontology Cellular component • cytoplasm Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100288142	n/a
Ensembl	ENSG00000203832	n/a
UniProt	Q6P3W6	n/a
RefSeq (mRNA)	NM_001039703.4	n/a
RefSeq (protein)	NP_001034792.3	n/a
Location (UCSC)	Chr 1: 148.25 – 148.36 Mb	n/a
PubMed search	[1]	n/a

Neuroblastoma breakpoint family member 10 is a protein that in Homo sapiens is encoded by the NBPF10 gene.^[1][2]

The full gene is 75,313 bp, with the major isoform of mRNA being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the DUF1220 repeats. The highly conserved, repeated region is believed to be originated from MGC8902. The NBPF family has been linked to primate evolution.^[2]. It is assumed to be related to the 1q21.1 deletion syndrome and 1q21.1 duplication syndrome.^[3]

Homology

Paralogs of NBPF10 includes other NBPF family members. Orthologs of NBPF10 are found in other primates; distant orthologs are found in bovine, equine, and canine

Functional role

Although NBPF10's function is unknown, there is reason to believe that NBPF10 is an important biomarker for the Odontoblast Phenotype^[4]

Gene Neighborhood

NOTCH2NL, SEC22B, HFE2, TXNIP are close neighbors of NBPF10. All of these neighboring genes are well studied in their own right.

Post-translational modification

NBPF10 has extremely low threonine content which may make the protein less susceptible to post-translational modification.^{[citation needed]}

References

1. ^ "Entrez Gene: NBPF10 neuroblastoma breakpoint family, member 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&DbFrom=protein&Cmd=Link&LinkName=protein_gene&IdsFromResult=291621653. Retrieved 28-April-2010. 
2. ^ ^{a b} Vandepoele K, Van Roy N, Staes K, Speleman F, van Roy F (November 2005). "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution". Mol. Biol. Evol. 22 (11): 2265–74. doi:10.1093/molbev/msi222. PMID 16079250. 
3. ^ e.g.: L. Dumas and J.M. Sikela; DUF1220 Domains, Cognitive Disease, and Human Brain Evolution; Advance 2009, doi: 10.1101/sqb.2009.74.025; Cold Spring Harbor Laboratory Press
4. ^ Butler W.T., Ritchie H. (February 1995). "The nature and functional significance of dentin extracellular matrix proteins.". Int J Dev Biol 39 (1): 169–79. PMID 7626404.