Nitroarginine

Nitroarginine
Nω-Nitro-L-arginine
IUPAC name
(2S)-2-Amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid
Other names
N5-(nitroamidino)-L-Ornithine; (+)-NG-Nitroarginine; NG-nitro-L-Arginine, L-NG-Nitroarginine; L-NNA; L-NOARG; NG-Nitro-L-arginine; NG-Nitroarginine; NOLA; NSC 53662; Nitro-L-arginine; Nω-Nitro-L-arginine; Nω-Nitro-L-arginine; ω-Nitro-L-arginine; ω-Nitroarginine
Identifiers
CAS number 2149-70-4
PubChem 440005
Jmol-3D images Image 1
Properties
Molecular formula C6H13N5O4
Molar mass 219.20 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Nitroarginine, or Nω-nitro-L-arginine, is a nitro derivative of the amino acid arginine. It is an inhibitor of nitric oxide synthase and hence a vaso-constrictor and coronary constrictor. As such, it finds widespread use as a biochemical tool in the study of nitric oxide and its biological effects.[1]

Nitroarginine has been used in research studying coronary constriction, in the presence of midazolam vasodilatation was unaffected by nitroarginine.[2]

References

  1. ^ Bansinath M; Arbabha B; Turndorf H; Garg U C (1993). "Chronic administration of a nitric oxide synthase inhibitor, N omega-nitro-L-arginine, and drug-induced increase in cerebellar cyclic GMP in vivo". Neurochemical research 18 (10): 1063–6. doi:10.1007/BF00966685. PMID 7504789. 
  2. ^ O.L. Woodman; G.J. Dusting (1991). "N-nitro L-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds". Br. J. Pharmacol. 103 (2): 1407–1410. PMC 1908370. PMID 1909199. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1908370. 


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