Technetium (99mTc) tetrofosmin

Technetium (^99mTc) tetrofosmin

Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Intravenous
Pharmacokinetic data
Bioavailability	N/A
Identifiers
CAS number	127455-27-0 127502-06-1 (tetrofosmin)
ATC code	V09GA02
Chemical data
Formula	C36H80O10P4Tc
Mol. mass	895.813 g/mol
Y(what is this?)  (99mTc) tetrofosmin (verify)

Technetium (^99mTc) tetrofosmin is a drug used in nuclear medicine cardiac imaging. It is sold under the brand name Myoview (GE Healthcare). The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin.^[1][2]

Tc-99m tetrofosmin is rapidly taken up by myocardial tissue and reaches its maximum level in approximately 5 minutes. 66% of the total injected dose is excreted within 48 hours after injection (40% urine, 26% feces). Tc-99m tetrofosmin is indicated for use in scintigraphic imaging of the myocardium under stress and rest conditions. It is used to determine areas of reversible ischemia and infarcted tissue in the heart. It is also indicated to detect changes in perfusion induced by pharmacologic stress (adenosine) in patients with coronary artery disease. Its third indication is to assess left ventricular function (ejection fraction) in patients thought to have heart disease. There are no known contraindications for use of Tc-99m tetrofosmin, but care should be taken to constantly monitor the cardiac function in patients with known or suspected coronary artery disease. Patients should be encouraged to void their bladder as soon as the images are gathered, and as often as possible after the exam to decrease their radiation dose, since the majority of elimination is renal. The recommended dose of Tc-99m tetrofosmin is between 5-33 millicuries (185-1221 megabecquerels). For a two dose stress/rest dosing, the typical dose is normally a 10 mCi dose, followed 1 to 4 hours later by a dose of 30 mCi. Imaging normally begins 15 minutes following injection.^[3]

References

1. ^ Kelly, JD; Alan M. Forster AM, Higley B, Archer CM et al. (February 1993). "Technetium-99m-Tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging". Journal of Nuclear Medicine 34 (2): 222–227. PMID 8429340. http://jnm.snmjournals.org/cgi/content/abstract/34/2/222. 
2. ^ Elhendy, A; Schinkel AF, van Domburg RT et al. (December 2005). "Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging". Journal of Nuclear Medicine 46 (12): 2003–2008. PMID 16330563. http://jnm.snmjournals.org/cgi/content/full/46/12/2003. 
3. ^ Myoview package insert. Arlington Heights, IL: GE Healthcare, 2006, Aug.

External links

Myoview Prescribing Information Page

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Radiopharmaceuticals Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Myōjinyama Myoxanthus exasperatus Look at other dictionaries: Technetium (99mTc) exametazime — Systematic (IUPAC) name [[(3RS,3 RS) 3,3 [(2,2 Dimethyltrimethylene)diimino][di 2 butanone]dioximato](3 ) N,N ,N ,N ]oxotechnetium (99mTc) …   Wikipedia Technetium (99mTc) sestamibi — MIBI scan redirects here. For the MIBG scan, see Iobenguane. Technetium (99mTc) sestamibi Systematic ( …   Wikipedia ATC code V09 — Section V09 of the Anatomical Therapeutic Chemical Classification System classifies diagnostic radiopharmaceuticals.V VariousV09A Central nervous systemV09AA Technetium (99mTc) compounds:V09AA01 Technetium (99mTc) exametazime:V09AA02 Technetium… …   Wikipedia Single photon emission computed tomography — (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera. However, it is able to provide true 3D information.… …   Wikipedia Perfusion scanning — Perfusion is defined as the passage of fluid through the lymphatic system or blood vessels to an organ or a tissue. [American Psychological Association (APA):perfusion. (n.d.). Dictionary.com Unabridged (v 1.1). Retrieved March 20, 2008, from… …   Wikipedia Iobenguane — MIBG scan redirects here. For the MIBI scan, see Technetium (99mTc) sestamibi. Iobenguane Systematic (IUPAC) name 1 (3 iodobenzyl)guanidine Clinical data …   Wikipedia Nuclear medicine — Intervention ICD 10 PCS C ICD 9: 92 …   Wikipedia Radionuclide — A radionuclide is an atom with an unstable nucleus, which is a nucleus characterized by excess energy available to be imparted either to a newly created radiation particle within the nucleus or to an atomic electron. The radionuclide, in this… …   Wikipedia Myokardszintigrafie — Die Myokardszintigrafie (MSZ) ist ein nuklearmedizinisches Untersuchungsverfahren, das je nach Durchführung Informationen über die Durchblutungs Verhältnisse, Vitalität und Funktion des Herzmuskels liefert. Inhaltsverzeichnis 1 Indikationen 1.1… …   Deutsch Wikipedia Scintigraphie myocardique — Le scintigraphie myocardique est un examen d imagerie médicale permettant de visualiser la fixation d un traceur radioactif sur le muscle cardiaque (myocarde), afin d apprécier la manière dont il est perfusé. Technique Elle consiste en l… …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”