Technetium (99mTc) tetrofosmin

Technetium (^99mTc) tetrofosmin

Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Intravenous
Pharmacokinetic data
Bioavailability	N/A
Identifiers
CAS number	127455-27-0 127502-06-1 (tetrofosmin)
ATC code	V09GA02
Chemical data
Formula	C36H80O10P4Tc
Mol. mass	895.813 g/mol
Y(what is this?)  (99mTc) tetrofosmin (verify)

Technetium (^99mTc) tetrofosmin is a drug used in nuclear medicine cardiac imaging. It is sold under the brand name Myoview (GE Healthcare). The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin.^[1][2]

Tc-99m tetrofosmin is rapidly taken up by myocardial tissue and reaches its maximum level in approximately 5 minutes. 66% of the total injected dose is excreted within 48 hours after injection (40% urine, 26% feces). Tc-99m tetrofosmin is indicated for use in scintigraphic imaging of the myocardium under stress and rest conditions. It is used to determine areas of reversible ischemia and infarcted tissue in the heart. It is also indicated to detect changes in perfusion induced by pharmacologic stress (adenosine) in patients with coronary artery disease. Its third indication is to assess left ventricular function (ejection fraction) in patients thought to have heart disease. There are no known contraindications for use of Tc-99m tetrofosmin, but care should be taken to constantly monitor the cardiac function in patients with known or suspected coronary artery disease. Patients should be encouraged to void their bladder as soon as the images are gathered, and as often as possible after the exam to decrease their radiation dose, since the majority of elimination is renal. The recommended dose of Tc-99m tetrofosmin is between 5-33 millicuries (185-1221 megabecquerels). For a two dose stress/rest dosing, the typical dose is normally a 10 mCi dose, followed 1 to 4 hours later by a dose of 30 mCi. Imaging normally begins 15 minutes following injection.^[3]

References

1. ^ Kelly, JD; Alan M. Forster AM, Higley B, Archer CM et al. (February 1993). "Technetium-99m-Tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging". Journal of Nuclear Medicine 34 (2): 222–227. PMID 8429340. http://jnm.snmjournals.org/cgi/content/abstract/34/2/222. 
2. ^ Elhendy, A; Schinkel AF, van Domburg RT et al. (December 2005). "Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging". Journal of Nuclear Medicine 46 (12): 2003–2008. PMID 16330563. http://jnm.snmjournals.org/cgi/content/full/46/12/2003. 
3. ^ Myoview package insert. Arlington Heights, IL: GE Healthcare, 2006, Aug.

External links

Myoview Prescribing Information Page

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