DIDS

DIDS
DIDS
Identifiers
Abbreviations DIDS
CAS number 53005-05-3 (E) YesY
PubChem 40600, 5281951 (E), 9548709 (Z)
ChemSpider 37094 YesY, 4445228 (E) YesY, 7827632 (Z) YesY
KEGG C11591
MeSH 4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid
ChEBI CHEBI:36511
Beilstein Reference 6543839
Jmol-3D images Image 1
Properties
Molecular formula C16H10N2O6S4
Molar mass 454.52 g mol−1
Exact mass 453.942168822 g mol-1
Melting point

400 °C, 673 K, 752 °F

log P 4.72
Acidity (pKa) -3.21, -1.428, -0.37, 0.23
Basicity (pKb) 13.77, 14.37, 15.425, 17.21
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor,[1] blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.[2]

References

  1. ^ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658 
  2. ^ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526