- DIDS
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DIDS 5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acidOther names5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acidIdentifiers Abbreviations DIDS CAS number 53005-05-3 (E) PubChem 40600, 5281951 (E), 9548709 (Z) ChemSpider 37094 , 4445228 (E) , 7827632 (Z) KEGG C11591 MeSH 4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid ChEBI CHEBI:36511 Beilstein Reference 6543839 Jmol-3D images Image 1 - OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S
- InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
Key: YSCNMFDFYJUPEF-UHFFFAOYSA-N
Properties Molecular formula C16H10N2O6S4 Molar mass 454.52 g mol−1 Exact mass 453.942168822 g mol-1 Melting point 400 °C, 673 K, 752 °F
log P 4.72 Acidity (pKa) -3.21, -1.428, -0.37, 0.23 Basicity (pKb) 13.77, 14.37, 15.425, 17.21 Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor,[1] blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.[2]
References
- ^ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658
- ^ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526
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