Copper ibuprofenate

Copper ibuprofenate
IUPAC name bis[2-(4-isobutylphenyl)propionato]copper(II)
Identifiers
CAS number	66840-44-6
Jmol-3D images	Image 1
SMILES [O-]C(C(C)C1=CC=C(CC(C)C)C=C1)=O.[O-]C(C(C)C1=CC=C(CC(C)C)C=C1)=O.[Cu2+]
Properties
Molecular formula	C26H36CuO4
Molar mass	476.11 g mol−1
Appearance	Green powder
Solubility in water	Slightly soluble
Solubility in isopropanol	Slightly soluble
Related compounds
Related compounds	Copper aspirinate Ibuprofen
Y ibuprofenate (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Copper ibuprofenate is a chemical complex consisting of copper(II) and the anionic form of the anti-inflammatory drug ibuprofen.^[1][2][3]

Usage

Research has suggested that copper complexes of anti-inflammatory drugs are more active than the drug by itself,^[1][4] and produce fewer gastrointestinal side-effects.^[5] In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.^[6][7]

References

1. ^ ^{a b} A. Latif, Abuhijleh (1997). "Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage". Polyhedron 16 (4): 733–740. doi:10.1016/0277-5387(96)00214-8. 
2. ^ Frazier, D. R.; S. K. Lynch and G. O. Carlisle (1981). "Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II)". Journal of Inorganic and Nuclear Chemistry 43 (11). doi:10.1016/0022-1902(81)80610-0. 
3. ^ Abuhijleh AL (September 1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem. 55 (4): 255–62. doi:10.1016/0162-0134(94)85010-0. PMID 7964714. 
4. ^ Sorenson JR (1989). "Copper complexes offer a physiological approach to treatment of chronic diseases". Prog Med Chem 26: 437–568. PMID 2690187. 
5. ^ Gordijo CR, Barbosa CA, Da Costa Ferreira AM, Constantino VR, de Oliveira Silva D (May 2005). "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci 94 (5): 1135–48. doi:10.1002/jps.20336. PMID 15793807. 
6. ^ "Ibuprofen complexes as wood preservatives - US pat. no, 7,462,227". US Patent Office. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7462227&OS=7462227&RS=7462227. Retrieved 1 February 2010. 
7. ^ "US Patent 7462227 - Ibuprofen complexes as wood preservatives". Patent Storm. http://www.patentstorm.us/patents/7462227/fulltext.html. Retrieved 1 February 2010.