Human immunodeficiency virus type 1 dimerization initiation site
- Human immunodeficiency virus type 1 dimerization initiation site
The Human immunodeficiency virus type 1 dimerization initiation site (HIV-1 DIS) is an RNA structure that is shown to promote dimerization of the HIV-1 genome via a loop-loop complex formation.
The HIV-1 DIS structure consists of a conserved hairpin structure with a palindromic loop sequence which was predicted and confirmed by mutagenesis [cite journal| title= Role of the DIS hairpin in replication of human immunodeficiency virus type 1 | id = PMID 8794309] .The Rfam structure is based on a covariation model.
This element forms part of a larger Retroviral Psi packaging element in the HIV genome.
References
ee also
Retroviral_Psi_packaging_element
External links
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