PRKAR2A

PRKAR2A

Protein kinase, cAMP-dependent, regulatory, type II, alpha, also known as PRKAR2A, is a human gene.

PBB_Summary
section_title =
summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [cite web | title = Entrez Gene: PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5576| accessdate = ]

ee also

* Protein kinase
* AMPK
* cAMP

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cho-Chung YS, Nesterova MV |title=Tumor reversion: protein kinase A isozyme switching. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 76–86 |year= 2006 |pmid= 16394127 |doi= 10.1196/annals.1359.014
*cite journal | author=Harrich D, McMillan N, Munoz L, "et al." |title=Will diverse Tat interactions lead to novel antiretroviral drug targets? |journal=Current drug targets |volume=7 |issue= 12 |pages= 1595–606 |year= 2007 |pmid= 17168834 |doi=
*cite journal | author=Skålhegg BS, Landmark B, Foss KB, "et al." |title=Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine RIIs. |journal=J. Biol. Chem. |volume=267 |issue= 8 |pages= 5374–9 |year= 1992 |pmid= 1544918 |doi=
*cite journal | author=Carr DW, Hausken ZE, Fraser ID, "et al." |title=Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13376–82 |year= 1992 |pmid= 1618839 |doi=
*cite journal | author=Hofmann B, Nishanian P, Baldwin RL, "et al." |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=
*cite journal | author=Scott JD, Stofko RE, McDonald JR, "et al." |title=Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=265 |issue= 35 |pages= 21561–6 |year= 1991 |pmid= 2147685 |doi=
*cite journal | author=Oyen O, Myklebust F, Scott JD, "et al." |title=Human testis cDNA for the regulatory subunit RII alpha of cAMP-dependent protein kinase encodes an alternate amino-terminal region. |journal=FEBS Lett. |volume=246 |issue= 1-2 |pages= 57–64 |year= 1989 |pmid= 2540040 |doi=
*cite journal | author=Obar RA, Dingus J, Bayley H, Vallee RB |title=The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C. |journal=Neuron |volume=3 |issue= 5 |pages= 639–45 |year= 1990 |pmid= 2561973 |doi=
*cite journal | author=Rubino HM, Dammerman M, Shafit-Zagardo B, Erlichman J |title=Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2. |journal=Neuron |volume=3 |issue= 5 |pages= 631–8 |year= 1990 |pmid= 2701845 |doi=
*cite journal | author=Hemmings BA, Aitken A, Cohen P, "et al." |title=Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5. |journal=Eur. J. Biochem. |volume=127 |issue= 3 |pages= 473–81 |year= 1983 |pmid= 6293815 |doi=
*cite journal | author=Hofmann B, Nishanian P, Nguyen T, "et al." |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=
*cite journal | author=Pariset C, Weinman S |title=Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: biochemical and cytochemical study. |journal=Mol. Reprod. Dev. |volume=39 |issue= 4 |pages= 415–22 |year= 1995 |pmid= 7893490 |doi= 10.1002/mrd.1080390410
*cite journal | author=Cheley S, Panchal RG, Carr DW, "et al." |title=Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2911–20 |year= 1994 |pmid= 7905481 |doi=
*cite journal | author=Hausken ZE, Coghlan VM, Hastings CA, "et al." |title=Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24245–51 |year= 1994 |pmid= 7929081 |doi=
*cite journal | author=Hofmann B, Nishanian P, Fan J, "et al." |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=
*cite journal | author=Beebe SJ, Salomonsky P, Holroyd C, Becker D |title=Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas. |journal=Cell Growth Differ. |volume=4 |issue= 12 |pages= 1005–12 |year= 1994 |pmid= 8117614 |doi=
*cite journal | author=Coghlan VM, Langeberg LK, Fernandez A, "et al." |title=Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=269 |issue= 10 |pages= 7658–65 |year= 1994 |pmid= 8125992 |doi=
*cite journal | author=Lester LB, Coghlan VM, Nauert B, Scott JD |title=Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9460–5 |year= 1996 |pmid= 8621616 |doi=
*cite journal | author=Foss KB, Solberg R, Simard J, "et al." |title=Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase. |journal=Biochim. Biophys. Acta |volume=1350 |issue= 1 |pages= 98–108 |year= 1997 |pmid= 9003463 |doi=
*cite journal | author=Dransfield DT, Bradford AJ, Smith J, "et al." |title=Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. |journal=EMBO J. |volume=16 |issue= 1 |pages= 35–43 |year= 1997 |pmid= 9009265 |doi= 10.1093/emboj/16.1.35

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