TARBP2

Tar (HIV-1) RNA binding protein 2, also known as TARBP2, is a human gene.cite web | title = Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6895| accessdate = ]

PBB_Summary
section_title =
summary_text = HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.cite web | title = Entrez Gene: TARBP2 Tar (HIV-1) RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6895| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gatignol A, Buckler-White A, Berkhout B, Jeang KT |title=Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. |journal=Science |volume=251 |issue= 5001 |pages= 1597–600 |year= 1991 |pmid= 2011739 |doi=
*cite journal | author=Cosentino GP, Venkatesan S, Serluca FC, "et al." |title=Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9445–9 |year= 1995 |pmid= 7568151 |doi=
*cite journal | author=Kozak CA, Gatignol A, Graham K, "et al." |title=Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). |journal=Genomics |volume=25 |issue= 1 |pages= 66–72 |year= 1995 |pmid= 7774957 |doi=
*cite journal | author=Gatignol A, Buckler C, Jeang KT |title=Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. |journal=Mol. Cell. Biol. |volume=13 |issue= 4 |pages= 2193–202 |year= 1993 |pmid= 8455607 |doi=
*cite journal | author=Gatignol A, Duarte M, Daviet L, "et al." |title=Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors. |journal=Gene Expr. |volume=5 |issue= 4-5 |pages= 217–28 |year= 1996 |pmid= 8723388 |doi=
*cite journal | author=Kasof GM, Goyal L, White E |title=Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4390–404 |year= 1999 |pmid= 10330179 |doi=
*cite journal | author=Daviet L, Erard M, Dorin D, "et al." |title=Analysis of a binding difference between the two dsRNA-binding domains in TRBP reveals the modular function of a KR-helix motif. |journal=Eur. J. Biochem. |volume=267 |issue= 8 |pages= 2419–31 |year= 2000 |pmid= 10759868 |doi=
*cite journal | author=Duarte M, Graham K, Daher A, "et al." |title=Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene. |journal=J. Biomed. Sci. |volume=7 |issue= 6 |pages= 494–506 |year= 2001 |pmid= 11060498 |doi=
*cite journal | author=Siffroi JP, Pawlak A, Alfonsi MF, "et al." |title=Expression of the TAR RNA binding protein in human testis. |journal=Mol. Hum. Reprod. |volume=7 |issue= 3 |pages= 219–25 |year= 2001 |pmid= 11228241 |doi=
*cite journal | author=Daher A, Longuet M, Dorin D, "et al." |title=Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33899–905 |year= 2001 |pmid= 11438532 |doi= 10.1074/jbc.M103584200
*cite journal | author=Iwasaki T, Chin WW, Ko L |title=Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33375–83 |year= 2001 |pmid= 11443112 |doi= 10.1074/jbc.M101517200
*cite journal | author=Bannwarth S, Talakoub L, Letourneur F, "et al." |title=Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 48803–13 |year= 2002 |pmid= 11641396 |doi= 10.1074/jbc.M104645200
*cite journal | author=Xu YC, Wu RF, Gu Y, "et al." |title=Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28051–7 |year= 2002 |pmid= 12023963 |doi= 10.1074/jbc.M202665200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Battisti PL, Daher A, Bannwarth S, "et al." |title=Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. |journal=AIDS Res. Hum. Retroviruses |volume=19 |issue= 9 |pages= 767–78 |year= 2003 |pmid= 14585207 |doi= 10.1089/088922203769232566
*cite journal | author=Lee JY, Kim H, Ryu CH, "et al." |title=Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity. |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30265–73 |year= 2004 |pmid= 15123692 |doi= 10.1074/jbc.M312083200
*cite journal | author=Haase AD, Jaskiewicz L, Zhang H, "et al." |title=TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. |journal=EMBO Rep. |volume=6 |issue= 10 |pages= 961–7 |year= 2006 |pmid= 16142218 |doi= 10.1038/sj.embor.7400509
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Bannwarth S, Lainé S, Daher A, "et al." |title=Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. |journal=J. Mol. Biol. |volume=355 |issue= 5 |pages= 898–910 |year= 2006 |pmid= 16343534 |doi= 10.1016/j.jmb.2005.11.026
*cite journal | author=Christensen HS, Daher A, Soye KJ, "et al." |title=Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. |journal=J. Virol. |volume=81 |issue= 10 |pages= 5121–31 |year= 2007 |pmid= 17360756 |doi= 10.1128/JVI.01511-06

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