TAGLN

Transgelin, also known as TAGLN, is a human gene.cite web | title = Entrez Gene: TAGLN transgelin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6876| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: TAGLN transgelin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6876| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Thweatt R, Lumpkin CK, Goldstein S |title=A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 1 |pages= 1–7 |year= 1992 |pmid= 1520290 |doi=
*cite journal | author=Nishida W, Kitami Y, Abe M, Hiwada K |title=Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. |journal=Biochem. Int. |volume=23 |issue= 4 |pages= 663–8 |year= 1991 |pmid= 1872880 |doi=
*cite journal | author=Nagase T, Miyajima N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=
*cite journal | author=Kobayashi R, Kubota T, Hidaka H |title=Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 1275–80 |year= 1994 |pmid= 8117285 |doi= 10.1006/bbrc.1994.1180
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Li L, Liu Z, Mercer B, "et al." |title=Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells. |journal=Dev. Biol. |volume=187 |issue= 2 |pages= 311–21 |year= 1997 |pmid= 9242426 |doi=
*cite journal | author=Yamamura H, Masuda H, Ikeda W, "et al." |title=Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation. |journal=J. Biochem. |volume=122 |issue= 1 |pages= 157–67 |year= 1997 |pmid= 9276683 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lawson D, Harrison M, Shapland C |title=Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines. |journal=Cell Motil. Cytoskeleton |volume=38 |issue= 3 |pages= 250–7 |year= 1998 |pmid= 9384215 |doi= 10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9 |doilabel=10.1002/(SICI)1097-0169(1997)38:3250::AID-CM33.0.CO;2-9
*cite journal | author=Camoretti-Mercado B, Forsythe SM, LeBeau MM, "et al." |title=Expression and cytogenetic localization of the human SM22 gene (TAGLN). |journal=Genomics |volume=49 |issue= 3 |pages= 452–7 |year= 1998 |pmid= 9615232 |doi= 10.1006/geno.1998.5267
*cite journal | author=Fu Y, Liu HW, Forsythe SM, "et al." |title=Mutagenesis analysis of human SM22: characterization of actin binding. |journal=J. Appl. Physiol. |volume=89 |issue= 5 |pages= 1985–90 |year= 2001 |pmid= 11053353 |doi=
*cite journal | author=Shields JM, Rogers-Graham K, Der CJ |title=Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9790–9 |year= 2002 |pmid= 11773051 |doi= 10.1074/jbc.M110086200
*cite journal | author=Chainiaux F, Magalhaes JP, Eliaers F, "et al." |title=UVB-induced premature senescence of human diploid skin fibroblasts. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 11 |pages= 1331–9 |year= 2002 |pmid= 12200029 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xu R, Ho YS, Ritchie RP, Li L |title=Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=284 |issue= 4 |pages= H1398–407 |year= 2003 |pmid= 12521938 |doi= 10.1152/ajpheart.00737.2002
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Yang Z, Chang YJ, Miyamoto H, "et al." |title=Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. |journal=Mol. Endocrinol. |volume=21 |issue= 2 |pages= 343–58 |year= 2007 |pmid= 17082327 |doi= 10.1210/me.2006-0104
*cite journal | author=Liao X, Li S, Lou Z, "et al." |title=Crystallization and preliminary crystallographic analysis of transgelin. |journal=Protein Pept. Lett. |volume=14 |issue= 2 |pages= 209–11 |year= 2007 |pmid= 17305610 |doi=
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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