Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3, also known as KIR3DL3, is a human gene.cite web | title = Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3| url =| accessdate = ]

section_title =
summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.cite web | title = Entrez Gene: KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Long EO, Barber DF, Burshtyn DN, "et al." |title=Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). |journal=Immunol. Rev. |volume=181 |issue= |pages= 223-33 |year= 2002 |pmid= 11513144 |doi=
*cite journal | author=Dou LP, Zheng DH, Wang C, "et al." |title=The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people. |journal=Int. J. Hematol. |volume= |issue= |pages= |year= |pmid= 18347914 |doi= 10.1007/s12185-008-0058-7
*cite journal | author=Pavlova Y, Kolesar L, Striz I, "et al." |title=Distribution of KIR genes in the Czech population. |journal=Int. J. Immunogenet. |volume=35 |issue= 1 |pages= 57-61 |year= 2008 |pmid= 18186800 |doi= 10.1111/j.1744-313X.2007.00737.x
*cite journal | author=Zhi-ming L, Yu-lian J, Zhao-lei F, "et al." |title=Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population. |journal=Croat. Med. J. |volume=48 |issue= 6 |pages= 800-6 |year= 2008 |pmid= 18074414 |doi=
*cite journal | author=Middleton D, Meenagh A, Sleator C, "et al." |title=No association of KIR genes with Behcet's disease. |journal=Tissue Antigens |volume=70 |issue= 5 |pages= 435-8 |year= 2007 |pmid= 17868255 |doi= 10.1111/j.1399-0039.2007.00929.x
*cite journal | author=Flores AC, Marcos CY, Paladino N, "et al." |title=KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. |journal=Tissue Antigens |volume=69 |issue= 6 |pages= 568-76 |year= 2007 |pmid= 17498266 |doi= 10.1111/j.1399-0039.2007.00824.x
*cite journal | author=Chen AM, Guo XM, Yan WY, "et al." |title= [Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia] |journal=Zhongguo Shi Yan Xue Ye Xue Za Zhi |volume=15 |issue= 1 |pages= 35-8 |year= 2007 |pmid= 17490516 |doi=
*cite journal | author=Jones DC, Hiby SE, Moffett A, "et al." |title=Nature of allelic sequence polymorphism at the KIR3DL3 locus. |journal=Immunogenetics |volume=58 |issue= 8 |pages= 614-27 |year= 2006 |pmid= 16823588 |doi= 10.1007/s00251-006-0130-5
*cite journal | author=Steiner NK, Hurley CK |title=KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions. |journal=Tissue Antigens |volume=67 |issue= 4 |pages= 277-83 |year= 2006 |pmid= 16634863 |doi= 10.1111/j.1399-0039.2006.00567.x
*cite journal | author=Zhu FM, Jiang K, Lü QF, "et al." |title= [Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population] |journal=Zhongguo Shi Yan Xue Ye Xue Za Zhi |volume=13 |issue= 6 |pages= 1109-12 |year= |pmid= 16403292 |doi=
*cite journal | author=Trundley AE, Hiby SE, Chang C, "et al." |title=Molecular characterization of KIR3DL3. |journal=Immunogenetics |volume=57 |issue= 12 |pages= 904-16 |year= 2006 |pmid= 16391939 |doi= 10.1007/s00251-005-0060-7
*cite journal | author=Jiang K, Zhu FM, Lv QF, Yan LX |title=Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. |journal=Tissue Antigens |volume=65 |issue= 6 |pages= 556-63 |year= 2005 |pmid= 15896204 |doi= 10.1111/j.1399-0039.2005.00412.x
*cite journal | author=Trompeter HI, Gómez-Lozano N, Santourlidis S, "et al." |title=Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. |journal=J. Immunol. |volume=174 |issue= 7 |pages= 4135-43 |year= 2005 |pmid= 15778373 |doi=
*cite journal | author=Arnheim L, Dillner J, Sanjeevi CB |title=A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia. |journal=Tissue Antigens |volume=65 |issue= 3 |pages= 252-9 |year= 2005 |pmid= 15730517 |doi= 10.1111/j.1399-0039.2005.00359.x
*cite journal | author=Norman PJ, Carrington CV, Byng M, "et al." |title=Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. |journal=Genes Immun. |volume=3 |issue= 2 |pages= 86-95 |year= 2002 |pmid= 11960306 |doi= 10.1038/sj.gene.6363836
*cite journal | author=Torkar M, Norgate Z, Colonna M, "et al." |title=Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex. |journal=Eur. J. Immunol. |volume=28 |issue= 12 |pages= 3959-67 |year= 1999 |pmid= 9862332 |doi=

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