OAZ2

OAZ2
Ornithine decarboxylase antizyme 2
Identifiers
Symbols OAZ2;
External IDs OMIM604152 MGI109492 HomoloGene31094 GeneCards: OAZ2 Gene
RNA expression pattern
PBB GE OAZ2 201364 s at tn.png
PBB GE OAZ2 201365 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4947 18247
Ensembl ENSG00000180304 ENSMUSG00000040652
UniProt O95190 O08608
RefSeq (mRNA) NM_002537 NM_010952.3
RefSeq (protein) NP_002528 NP_035082.1
Location (UCSC) Chr 15:
64.98 – 64.98 Mb
Chr 9:
65.47 – 65.49 Mb
PubMed search [1] [2]

Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.[1][2][3]

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.[3]

References

  1. ^ Ivanov IP, Gesteland RF, Atkins JF (Dec 1998). "A second mammalian antizyme: conservation of programmed ribosomal frameshifting". Genomics 52 (2): 119–29. doi:10.1006/geno.1998.5434. PMID 9782076. 
  2. ^ Zhou J, Atkins JF, Gesteland RF (Jul 1999). "Structure of human ornithine decarboxylase antizyme 2 gene". Gene 232 (2): 165–71. doi:10.1016/S0378-1119(99)00128-6. PMID 10352227. 
  3. ^ a b "Entrez Gene: OAZ2 ornithine decarboxylase antizyme 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4947. 

Further reading




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  • Ornithine decarboxylase antizyme — is a ornithine decarboxylase inhibitor. It was first characterized in 1981.[1] The genes include OAZ1, OAZ2, and OAZ3. References ^ …   Wikipedia

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