DHX15

DEAH (Asp-Glu-Ala-His) box polypeptide 15
Identifiers
Symbols	DHX15; DBP1; DDX15; HRH2; PRP43; PRPF43; PrPp43p
External IDs	OMIM: 603403 MGI: 1099786 HomoloGene: 1040 GeneCards: DHX15 Gene
EC number	3.6.4.13
Gene Ontology Molecular function • nucleotide binding • nucleic acid binding • RNA helicase activity • ATP binding • ATP-dependent helicase activity • hydrolase activity Cellular component • nucleus • U12-type spliceosomal complex Biological process • mRNA processing • RNA splicing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1665	13204
Ensembl	ENSG00000109606	ENSMUSG00000029169
UniProt	O43143	Q3TFE5
RefSeq (mRNA)	NM_001358	NM_001042620
RefSeq (protein)	NP_001349	NP_001036085
Location (UCSC)	Chr 4: 24.52 – 24.59 Mb	Chr 5: 52.54 – 52.58 Mb
PubMed search	[1]	[2]

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^[1][2]

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing.^[2]

References

1. ^ Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478. 
2. ^ ^{a b} "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1665. 

Further reading

• Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370585. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349. PMID 12458796. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370349. 
• Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. PMC 359297. PMID 7935475. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359297.