NXF2

Nuclear RNA export factor 2
Identifiers
Symbols	NXF2; CT39; FLJ20416; NXF2B; TAPL-2
External IDs	OMIM: 300315 MGI: 2159343 HomoloGene: 88604 GeneCards: NXF2 Gene
Gene Ontology Molecular function • nucleotide binding • RNA binding • protein binding Cellular component • intracellular • nucleus • cytoplasm • nuclear RNA export factor complex Biological process • mRNA export from nucleus • transport • multicellular organismal development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56001	170722
Ensembl	n/a	ENSMUSG00000031410
UniProt	Q9GZY0	n/a
RefSeq (mRNA)	NM_017809.3	NM_130888.1
RefSeq (protein)	NP_060279.2	NP_570958.1
Location (UCSC)	n/a	Chr X: 132.11 – 132.13 Mb
PubMed search	[1]	[2]

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.^[1][2][3]

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.^[3]

Interactions

NXF2 has been shown to interact with NUP214.^[1]

References

1. ^ ^{a b} Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol Cell Biol 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86553. 
2. ^ Wang PJ, McCarrey JR, Yang F, Page DC (Mar 2001). "An abundance of X-linked genes expressed in spermatogonia". Nat Genet 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. 
3. ^ ^{a b} "Entrez Gene: NXF2 nuclear RNA export factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56001. 

Further reading

• Black BE, Lévesque L, Holaska JM et al. (2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol. Cell. Biol. 19 (12): 8616–24. PMC 84993. PMID 10567585. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84993. 
• Jun L, Frints S, Duhamel H et al. (2002). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Curr. Biol. 11 (18): 1381–1391. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–337. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. 

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