DRD1IP

Calcyon neuron-specific vesicular protein
Identifiers
Symbols	CALY; DRD1IP; NSG3
External IDs	OMIM: 604647 MGI: 1915816 HomoloGene: 9256 GeneCards: CALY Gene
Gene Ontology Molecular function • clathrin light chain binding • dopamine receptor binding Cellular component • plasma membrane • integral to plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • dopamine receptor signaling pathway • positive regulation of endocytosis • clathrin coat assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50632	68566
Ensembl	ENSG00000130643	ENSMUSG00000025468
UniProt	Q9NYX4	Q9DCA7
RefSeq (mRNA)	NM_015722.3	NM_026769
RefSeq (protein)	NP_056537.1	NP_081045
Location (UCSC)	Chr 10: 135.14 – 135.15 Mb	Chr 7: 147.26 – 147.27 Mb
PubMed search	[1]	[2]

Neuron-specific vesicular protein calcyon is a protein that in humans is encoded by the CALY gene.^[1][2][3] Its alternative name is Calcyon.

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs.^[3]

References

1. ^ Lezcano N, Mrzljak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C (Mar 2000). "Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein". Science 287 (5458): 1660–4. doi:10.1126/science.287.5458.1660. PMID 10698743. 
2. ^ Heijtz RD, Alexeyenko A, Castellanos FX (Aug 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD". Behav Brain Funct 3 (1): 33. doi:10.1186/1744-9081-3-33. PMC 1949817. PMID 17623072. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1949817. 
3. ^ ^{a b} "Entrez Gene: DRD1IP dopamine receptor D1 interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50632. 

Further reading

• Milligan G, White JH (2001). "Protein-protein interactions at G-protein-coupled receptors.". Trends Pharmacol. Sci. 22 (10): 513–8. doi:10.1016/S0165-6147(00)01801-0. PMID 11583808. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ali MK, Bergson C (2004). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane.". J. Biol. Chem. 278 (51): 51654–63. doi:10.1074/jbc.M305803200. PMID 14534309. 
• Luo X, Kranzler H, Lappalainen J, et al. (2005). "CALCYON gene variation, schizophrenia, and cocaine dependence.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 25–30. doi:10.1002/ajmg.b.20092. PMID 14755439. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Laurin N, Misener VL, Crosbie J, et al. (2006). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder.". Mol. Psychiatry 10 (12): 1117–25. doi:10.1038/sj.mp.4001737. PMID 16172615. 
• Xiao J, Dai R, Negyessy L, Bergson C (2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.". J. Biol. Chem. 281 (22): 15182–93. doi:10.1074/jbc.M600265200. PMID 16595675. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Kruusmägi M, Zelenin S, Brismar H, Scott L (2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein.". Neuroreport 18 (15): 1547–51. doi:10.1097/WNR.0b013e3282f03f51. PMID 17885599.