- TSPAN8
Tetraspanin 8, also known as TSPAN8, is a human
gene .cite web | title = Entrez Gene: TSPAN8 tetraspanin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7103| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex withintegrins . This gene is expressed in differentcarcinomas . The use of alternate polyadenylation sites has been found for this gene.cite web | title = Entrez Gene: TSPAN8 tetraspanin 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7103| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Szala S, Kasai Y, Steplewski Z, "et al." |title=Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 17 |pages= 6833–7 |year= 1990 |pmid= 2395876 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Gwynn B, Eicher EM, Peters LL |title=Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. |journal=Genomics |volume=35 |issue= 2 |pages= 389–91 |year= 1996 |pmid= 8661157 |doi= 10.1006/geno.1996.0375
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Serru V, Le Naour F, Billard M, "et al." |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 103–11 |year= 1999 |pmid= 10229664 |doi=
*cite journal | author=Kanetaka K, Sakamoto M, Yamamoto Y, "et al." |title=Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. |journal=J. Hepatol. |volume=35 |issue= 5 |pages= 637–42 |year= 2002 |pmid= 11690710 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shackel NA, McGuinness PH, Abbott CA, "et al." |title=Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization. |journal=Hepatology |volume=38 |issue= 3 |pages= 577–88 |year= 2003 |pmid= 12939584 |doi= 10.1053/jhep.2003.50376
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kuhn S, Koch M, Nübel T, "et al." |title=A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. |journal=Mol. Cancer Res. |volume=5 |issue= 6 |pages= 553–67 |year= 2007 |pmid= 17579117 |doi= 10.1158/1541-7786.MCR-06-0384PBB_Controls
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