- VPS33B
Vacuolar protein sorting 33 homolog B (yeast), also known as VPS33B, is a human
gene .cite web | title = Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26276| accessdate = ]PBB_Summary
section_title =
summary_text = Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.cite web | title = Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26276| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Pevsner J, Hsu SC, Hyde PS, Scheller RH |title=Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking. |journal=Gene |volume=183 |issue= 1-2 |pages= 7–14 |year= 1997 |pmid= 8996080 |doi=
*cite journal | author=Carim L, Sumoy L, Andreu N, "et al." |title=Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 92–5 |year= 2000 |pmid= 10894945 |doi=
*cite journal | author=Huizing M, Didier A, Walenta J, "et al." |title=Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33. |journal=Gene |volume=264 |issue= 2 |pages= 241–7 |year= 2001 |pmid= 11250079 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gissen P, Johnson CA, Morgan NV, "et al." |title=Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome. |journal=Nat. Genet. |volume=36 |issue= 4 |pages= 400–4 |year= 2004 |pmid= 15052268 |doi= 10.1038/ng1325
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gissen P, Johnson CA, Gentle D, "et al." |title=Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. |journal=Hum. Mol. Genet. |volume=14 |issue= 10 |pages= 1261–70 |year= 2005 |pmid= 15790593 |doi= 10.1093/hmg/ddi137
*cite journal | author=Lo B, Li L, Gissen P, "et al." |title=Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. |journal=Blood |volume=106 |issue= 13 |pages= 4159–66 |year= 2006 |pmid= 16123220 |doi= 10.1182/blood-2005-04-1356
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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