NT5C

5', 3'-nucleotidase, cytosolic
Identifiers
Symbols	NT5C; DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; dNT-1
External IDs	OMIM: 191720 MGI: 1354954 HomoloGene: 8745 GeneCards: NT5C Gene
EC number	3.1.3.5
Gene Ontology Molecular function • nucleotidase activity • 5'-nucleotidase activity • hydrolase activity • pyrimidine nucleotide binding • metal ion binding Cellular component • nucleus • cytoplasm • mitochondrion • cytosol Biological process • purine base metabolic process • purine nucleotide catabolic process • pyrimidine base metabolic process • nucleotide metabolic process • pyrimidine deoxyribonucleotide catabolic process • dephosphorylation • pyrimidine nucleoside catabolic process • nucleobase, nucleoside and nucleotide metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30833	50773
Ensembl	ENSG00000125458	ENSMUSG00000020736
UniProt	Q8TCD5	Q9JM14
RefSeq (mRNA)	NM_014595	NM_015807.1
RefSeq (protein)	NP_055410	NP_056622.1
Location (UCSC)	Chr 17: 73.13 – 73.13 Mb	Chr 11: 115.35 – 115.35 Mb
PubMed search	[1]	[2]

5'(3')-deoxyribonucleotidase, cytosolic type is an enzyme that in humans is encoded by the NT5C gene.^[1][2]

Pyrimidine 5-prime nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1; MIM 606224) and type II (UMPH2).[supplied by OMIM]^[2]

References

1. ^ Rampazzo C, Gallinaro L, Milanesi E, Frigimelica E, Reichard P, Bianchi V (Aug 2000). "A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease". Proc Natl Acad Sci U S A 97 (15): 8239–44. doi:10.1073/pnas.97.15.8239. PMC 26931. PMID 10899995. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26931. 
2. ^ ^{a b} "Entrez Gene: NT5C 5', 3'-nucleotidase, cytosolic". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30833. 

Further reading

• Höglund L, Reichard P (1990). "Cytoplasmic 5'(3')-nucleotidase from human placenta". J. Biol. Chem. 265 (12): 6589–95. PMID 2157703. 
• Wilson DE, Swallow DM, Povey S (1988). "Assignment of the human gene for uridine 5'-monophosphate phosphohydrolase (UMPH2) to the long arm of chromosome 17". Ann. Hum. Genet. 50 (Pt 3): 223–7. doi:10.1111/j.1469-1809.1986.tb01042.x. PMID 2833155. 
• Xu WM, Gorman PA, Rider SH, et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. doi:10.1073/pnas.85.22.8563. PMC 282499. PMID 3186746. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=282499. 
• Rampazzo C, Johansson M, Gallinaro L, et al. (2000). "Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells". J. Biol. Chem. 275 (8): 5409–15. doi:10.1074/jbc.275.8.5409. PMID 10681516. 
• Rampazzo C, Kost-Alimova M, Ruzzenente B, et al. (2003). "Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs". Gene 294 (1–2): 109–17. doi:10.1016/S0378-1119(02)00651-0. PMID 12234672. 
• Amici A, Emanuelli M, Ruggieri S, et al. (2003). Kinetic evidence for covalent phosphoryl-enzyme intermediate in phosphotransferase activity of human red cell pyrimidine nucleotidases. "Kinetic evidence for covalent phosphoryl-enzyme intermediate in phosphotransferase activity of human red cell pyrimidine nucleotidases". Meth. Enzymol.. Methods in Enzymology 354: 149–59. doi:10.1016/S0076-6879(02)54011-8. ISBN 9780121822576. PMID 12418222. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Balta G, Gumruk F, Akarsu N, et al. (2003). "Molecular characterization of Turkish patients with pyrimidine 5' nucleotidase-I deficiency". Blood 102 (5): 1900–3. doi:10.1182/blood-2003-02-0628. PMID 12714505. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Galmarini CM, Cros E, Graham K, et al. (2006). "5'-(3')-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine". Haematologica 89 (5): 617–9. PMID 15136231. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.