- TSPAN4
Tetraspanin 4, also known as TSPAN4, is a human
gene .cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: TSPAN4 tetraspanin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7106| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Tachibana I, Bodorova J, Berditchevski F, "et al." |title=NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29181–9 |year= 1997 |pmid= 9360996 |doi=
*cite journal | author=Todd SC, Doctor VS, Levy S |title=Sequences and expression of six new members of the tetraspanin/TM4SF family. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 1 |pages= 101–4 |year= 1998 |pmid= 9714763 |doi=
*cite journal | author=Serru V, Le Naour F, Billard M, "et al." |title=Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 103–11 |year= 1999 |pmid= 10229664 |doi=
*cite journal | author=Yauch RL, Kazarov AR, Desai B, "et al." |title=Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9230–8 |year= 2000 |pmid= 10734060 |doi=
*cite journal | author=Lozahic S, Christiansen D, Manié S, "et al." |title=CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 900–7 |year= 2000 |pmid= 10741407 |doi= 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X |doilabel=10.1002/1521-4141(200003)30:3900::AID-IMMU9003.0.CO;2-X
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark AG, Glanowski S, Nielsen R, "et al." |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2PBB_Controls
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