NPDC1

Neural proliferation, differentiation and control, 1
Identifiers
Symbols	NPDC1; CAB; CAB-; CAB-1; CAB1; DKFZp586J0523; NPDC-1
External IDs	OMIM: 605798 MGI: 1099802 HomoloGene: 32050 GeneCards: NPDC1 Gene
Gene Ontology Cellular component • membrane • integral to membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56654	18146
Ensembl	ENSG00000107281	ENSMUSG00000015094
UniProt	Q9NQX5	Q925Q2
RefSeq (mRNA)	NM_015392	NM_008721.3
RefSeq (protein)	NP_056207	NP_032747.2
Location (UCSC)	Chr 9: 139.93 – 139.94 Mb	Chr 2: 25.25 – 25.27 Mb
PubMed search	[1]	[2]

Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.^[1][2]

Interactions

NPDC1 has been shown to interact with E2F1.^[3]

References

1. ^ Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (Mar 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976. 
2. ^ "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56654. 
3. ^ Sansal, I; Dupont E, Toru D, Evrard C, Rouget P (Oct. 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene (ENGLAND) 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. ISSN 0950-9232. PMID 11042687. 

Further reading

• Dupont E, Sansal I, Toru D, et al. (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Seances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131. 
• Galiana E, Vernier P, Dupont E, et al. (1995). "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation.". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1560–4. doi:10.1073/pnas.92.5.1560. PMC 42559. PMID 7878019. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42559. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302062. 
• Sansal I, Dupont E, Toru D, et al. (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi:10.1074/jbc.M402507200. PMID 15229225. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Evrard C, Caron S, Rouget P (2005). "Functional analysis of the NPDC-1 gene". Gene 343 (1): 153–63. doi:10.1016/j.gene.2004.08.020. PMID 15563841. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.