RhoH

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] It is encoded by the gene RHOHcite web | title = Entrez Gene: RHOH ras homolog gene family, member H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=399| accessdate = ] .

Gene

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.cite web | title = Entrez Gene: RHOH ras homolog gene family, member H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=399| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, "et al." |title=TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. |journal=Oncogene |volume=10 |issue= 11 |pages= 2171–8 |year= 1995 |pmid= 7784061 |doi=
*cite journal | author=Dallery-Prudhomme E, Roumier C, Denis C, "et al." |title=Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. |journal=Genomics |volume=43 |issue= 1 |pages= 89–94 |year= 1997 |pmid= 9226377 |doi= 10.1006/geno.1997.4788
*cite journal | author=Yousefi S, Cooper PR, Mueck B, "et al." |title=cDNA representational difference analysis of human neutrophils stimulated by GM-CSF. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 2 |pages= 401–9 |year= 2000 |pmid= 11032736 |doi= 10.1006/bbrc.2000.3678
*cite journal | author=Fauré J, Dagher MC |title=Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI). |journal=Biochimie |volume=83 |issue= 5 |pages= 409–14 |year= 2001 |pmid= 11368848 |doi=
*cite journal | author=Li X, Bu X, Lu B, "et al." |title=The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. |journal=Mol. Cell. Biol. |volume=22 |issue= 4 |pages= 1158–71 |year= 2002 |pmid= 11809807 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lahousse S, Smorowski AL, Denis C, "et al." |title=Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. |journal=Gene |volume=343 |issue= 1 |pages= 55–68 |year= 2005 |pmid= 15563831 |doi= 10.1016/j.gene.2004.08.022
*cite journal | author=Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, "et al." |title=Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 648–54 |year= 2005 |pmid= 15670823 |doi= 10.1016/j.febslet.2004.12.039
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Reiniger L, Bödör C, Bognár A, "et al." |title=Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. |journal=Leukemia |volume=20 |issue= 6 |pages= 1089–95 |year= 2006 |pmid= 16541139 |doi= 10.1038/sj.leu.2404183
*cite journal | author=Hiraga J, Katsumi A, Iwasaki T, "et al." |title=Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. |journal=Leukemia |volume=21 |issue= 8 |pages= 1846–7 |year= 2007 |pmid= 17443219 |doi= 10.1038/sj.leu.2404717
*cite journal | author=Traverse-Glehen A, Verney A, Baseggio L, "et al." |title=Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin. |journal=Leukemia |volume=21 |issue= 8 |pages= 1821–4 |year= 2007 |pmid= 17476282 |doi= 10.1038/sj.leu.2404706

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes