PDCD10

Programmed cell death 10
Rendering based on PDB 3AJM.
Available structures PDB 3AJM, 3L8I, 3L8J
Identifiers
Symbols	PDCD10; CCM3; MGC1212; MGC24477; TFAR15
External IDs	OMIM: 609118 MGI: 1928396 HomoloGene: 10505 GeneCards: PDCD10 Gene
Gene Ontology Molecular function • protein binding • protein homodimerization activity • protein N-terminus binding Cellular component • Golgi membrane • cytoplasm • Golgi apparatus • cytosol • plasma membrane Biological process • angiogenesis • positive regulation of cell proliferation • negative regulation of apoptosis • positive regulation of MAP kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11235	56426
Ensembl	ENSG00000114209	ENSMUSG00000027835
UniProt	Q9BUL8	Q3TVB4
RefSeq (mRNA)	NM_007217.3	NM_019745.3
RefSeq (protein)	NP_009148.2	NP_062719.2
Location (UCSC)	Chr 3: 167.4 – 167.45 Mb	Chr 3: 75.32 – 75.36 Mb
PubMed search	[1]	[2]

Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene.^[1][2]

This gene encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene.^[2]

Interactions

PDCD10 has been shown to interact with RP6-213H19.1,^[3] STK25,^[3][4] STRN,^[3] STRN3,^[3] MOBKL3,^[3] CTTNBP2NL,^[3] STK24^[3][4][5] and FAM40A.^[3]

References

1. ^ Bergametti F, Denier C, Labauge P, Arnoult M, Boetto S, Clanet M, Coubes P, Echenne B, Ibrahim R, Irthum B, Jacquet G, Lonjon M, Moreau JJ, Neau JP, Parker F, Tremoulet M, Tournier-Lasserve E (Dec 2004). "Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations". Am J Hum Genet 76 (1): 42–51. doi:10.1086/426952. PMC 1196432. PMID 15543491. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1196432. 
2. ^ ^{a b} "Entrez Gene: PDCD10 programmed cell death 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11235. 
3. ^ ^{a b c d e f g h} Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (Jan. 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2621004. 
4. ^ ^{a b} Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

Further reading

• Craig HD, Günel M, Cepeda O, et al. (1998). "Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.". Hum. Mol. Genet. 7 (12): 1851–8. doi:10.1093/hmg/7.12.1851. PMID 9811928. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Guclu B, Ozturk AK, Pricola KL, et al. (2006). "Cerebral venous malformations have distinct genetic origin from cerebral cavernous malformations.". Stroke 36 (11): 2479–80. doi:10.1161/01.STR.0000183616.99139.d3. PMID 16239636. 
• Guclu B, Ozturk AK, Pricola KL, et al. (2006). "Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.". Neurosurgery 57 (5): 1008–13. doi:10.1227/01.NEU.0000180811.56157.E1. PMID 16284570. 
• Liquori CL, Berg MJ, Squitieri F, et al. (2006). "Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.". Hum. Mutat. 27 (1): 118. doi:10.1002/humu.9389. PMID 16329096. 
• Verlaan DJ, Roussel J, Laurent SB, et al. (2006). "CCM3 mutations are uncommon in cerebral cavernous malformations.". Neurology 65 (12): 1982–3. doi:10.1212/01.wnl.0000188903.75144.49. PMID 16380626. 
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941. 
• Labauge P, Krivosic V, Denier C, et al. (2006). "Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study.". Arch. Ophthalmol. 124 (6): 885–6. doi:10.1001/archopht.124.6.885. PMID 16769843. 
• Chen PY, Chang WS, Chou RH, et al. (2007). "Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner.". BMC Mol. Biol. 8: 2. doi:10.1186/1471-2199-8-2. PMC 1796892. PMID 17212813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1796892. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Ma X, Zhao H, Shan J, et al. (2007). "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.". Mol. Biol. Cell 18 (6): 1965–78. doi:10.1091/mbc.E06-07-0608. PMC 1877091. PMID 17360971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1877091.