LTK (gene)

Leukocyte tyrosine kinase, also known as LTK, is a human gene.cite web | title = Entrez Gene: LTK leukocyte tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4058| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: LTK leukocyte tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4058| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Krolewski JJ, Dalla-Favera R |title=The ltk gene encodes a novel receptor-type protein tyrosine kinase. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2911–9 |year= 1991 |pmid= 1655406 |doi=
*cite journal | author=Krolewski JJ, Lee R, Eddy R, "et al." |title=Identification and chromosomal mapping of new human tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 3 |pages= 277–82 |year= 1990 |pmid= 2156206 |doi=
*cite journal | author=Maru Y, Hirai H, Takaku F |title=Human ltk: gene structure and preferential expression in human leukemic cells. |journal=Oncogene Res. |volume=5 |issue= 3 |pages= 199–204 |year= 1990 |pmid= 2320375 |doi=
*cite journal | author=Ben-Neriah Y, Bauskin AR |title=Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. |journal=Nature |volume=333 |issue= 6174 |pages= 672–6 |year= 1988 |pmid= 2836739 |doi= 10.1038/333672a0
*cite journal | author=Toyoshima H, Kozutsumi H, Maru Y, "et al." |title=Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5404–8 |year= 1993 |pmid= 7685902 |doi=
*cite journal | author=Richard I, Broux O, Chiannilkulchai N, "et al." |title=Regional localization of human chromosome 15 loci. |journal=Genomics |volume=23 |issue= 3 |pages= 619–27 |year= 1995 |pmid= 7851890 |doi=
*cite journal | author=Kozutsumi H, Toyoshima H, Hagiwara K, "et al." |title=Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. |journal=Oncogene |volume=9 |issue= 10 |pages= 2991–8 |year= 1994 |pmid= 8084603 |doi=
*cite journal | author=Kozutsumi H, Toyoshima H, Hagiwara K, "et al." |title=Identification of the human ltk gene product in placenta and hematopoietic cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 2 |pages= 674–9 |year= 1993 |pmid= 8427607 |doi= 10.1006/bbrc.1993.1101
*cite journal | author=Ueno H, Sasaki K, Kozutsumi H, "et al." |title=Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27707–14 |year= 1996 |pmid= 8910363 |doi=
*cite journal | author=Snijders AJ, Ho SC, Haase VH, "et al." |title=A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1297–301 |year= 1997 |pmid= 8995435 |doi=
*cite journal | author=Ueno H, Honda H, Nakamoto T, "et al." |title=The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. |journal=Oncogene |volume=14 |issue= 25 |pages= 3067–72 |year= 1997 |pmid= 9223670 |doi= 10.1038/sj.onc.1201153
*cite journal | author=Espanel X, Huguenin-Reggiani M, Van Huijsduijnen RH |title=The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. |journal=Protein Sci. |volume=11 |issue= 10 |pages= 2326–34 |year= 2003 |pmid= 12237455 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li N, Nakamura K, Jiang Y, "et al." |title=Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. |journal=Hum. Mol. Genet. |volume=13 |issue= 2 |pages= 171–9 |year= 2004 |pmid= 14695357 |doi= 10.1093/hmg/ddh020

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