TSLP

Thymic stromal lymphopoietin, also known as TSLP, is a human gene.

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants.cite web | title = Entrez Gene: TSLP thymic stromal lymphopoietin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85480| accessdate = ]

TSLP are produced mainly by non-hematopoietic cells as fibroblasts, epithelial cells and different types of stromal or stromal-like cells.Fact|date=September 2008 These producers seem to be specific for the location and the conditions under which TSLP is produced. For example expression of TSLP is enhanced under asthma-like conditions (aka Airway HyperResponsiveness or AHR model in the mouse), conditioning antigen-presenting cells (APCs) in order to orientate the differentiation of T cells coming into the lungs towards a TH2 profile (T helper 2 pathway).Fact|date=September 2008 The TH2 cells then release factors promoting an inflammatory reaction following the repeated contact with a specific antigen in the airways. The factors inducing the activation of TSLP release are not clearly defined.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Soumelis V, Liu YJ |title=Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation. |journal=Springer Semin. Immunopathol. |volume=25 |issue= 3-4 |pages= 325–33 |year= 2004 |pmid= 14999427 |doi= 10.1007/s00281-003-0152-0
*cite journal | author=Ziegler SF, Liu YJ |title=Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. |journal=Nat. Immunol. |volume=7 |issue= 7 |pages= 709–14 |year= 2006 |pmid= 16785889 |doi= 10.1038/ni1360
*cite journal | author=Liu YJ |title=Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. |journal=J. Allergy Clin. Immunol. |volume=120 |issue= 2 |pages= 238–44; quiz 245–6 |year= 2007 |pmid= 17666213 |doi= 10.1016/j.jaci.2007.06.004
*cite journal | author=Isaksen DE, Baumann H, Trobridge PA, "et al." |title=Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. |journal=J. Immunol. |volume=163 |issue= 11 |pages= 5971–7 |year= 1999 |pmid= 10570284 |doi=
*cite journal | author=Reche PA, Soumelis V, Gorman DM, "et al." |title=Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. |journal=J. Immunol. |volume=167 |issue= 1 |pages= 336–43 |year= 2001 |pmid= 11418668 |doi=
*cite journal | author=Quentmeier H, Drexler HG, Fleckenstein D, "et al." |title=Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. |journal=Leukemia |volume=15 |issue= 8 |pages= 1286–92 |year= 2001 |pmid= 11480573 |doi=10.1038/sj.leu.2402175
*cite journal | author=Soumelis V, Reche PA, Kanzler H, "et al." |title=Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. |journal=Nat. Immunol. |volume=3 |issue= 7 |pages= 673–80 |year= 2002 |pmid= 12055625 |doi= 10.1038/ni805
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gilliet M, Soumelis V, Watanabe N, "et al." |title=Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. |journal=J. Exp. Med. |volume=197 |issue= 8 |pages= 1059–63 |year= 2003 |pmid= 12707303 |doi= 10.1084/jem.20030240
*cite journal | author=Watanabe N, Hanabuchi S, Marloie-Provost MA, "et al." |title=Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. |journal=Blood |volume=105 |issue= 12 |pages= 4749–51 |year= 2005 |pmid= 15741223 |doi= 10.1182/blood-2004-09-3622
*cite journal | author=Ying S, O'Connor B, Ratoff J, "et al." |title=Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. |journal=J. Immunol. |volume=174 |issue= 12 |pages= 8183–90 |year= 2005 |pmid= 15944327 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lee HC, Ziegler SF |title=Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 3 |pages= 914–9 |year= 2007 |pmid= 17213320 |doi= 10.1073/pnas.0607305104
*cite journal | author=Ebner S, Nguyen VA, Forstner M, "et al." |title=Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells. |journal=J. Allergy Clin. Immunol. |volume=119 |issue= 4 |pages= 982–90 |year= 2007 |pmid= 17320941 |doi= 10.1016/j.jaci.2007.01.003
*cite journal | author=Koyama K, Ozawa T, Hatsushika K, "et al." |title=A possible role for TSLP in inflammatory arthritis. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 99–104 |year= 2007 |pmid= 17416344 |doi= 10.1016/j.bbrc.2007.03.081
*cite journal | author=Zhang K, Shan L, Rahman MS, "et al." |title=Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=293 |issue= 2 |pages= L375–82 |year= 2007 |pmid= 17513456 |doi= 10.1152/ajplung.00045.2007
*cite journal | author=Rochman I, Watanabe N, Arima K, "et al." |title=Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 6720–4 |year= 2007 |pmid= 17513717 |doi=
*cite journal | author=Wang YH, Angkasekwinai P, Lu N, "et al." |title=IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. |journal=J. Exp. Med. |volume=204 |issue= 8 |pages= 1837–47 |year= 2007 |pmid= 17635955 |doi= 10.1084/jem.20070406

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