- IL25
Interleukin 25, also known as IL25, is a human
gene .cite web | title = Entrez Gene: IL25 interleukin 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64806| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.cite web | title = Entrez Gene: IL25 interleukin 25| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64806| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Lee J, Ho WH, Maruoka M, "et al." |title=IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 1660–4 |year= 2001 |pmid= 11058597 |doi= 10.1074/jbc.M008289200
*cite journal | author=Pan G, French D, Mao W, "et al." |title=Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6559–67 |year= 2002 |pmid= 11714825 |doi=
*cite journal | author=Fort MM, Cheung J, Yen D, "et al." |title=IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. |journal=Immunity |volume=15 |issue= 6 |pages= 985–95 |year= 2002 |pmid= 11754819 |doi=
*cite journal | author=Kim MR, Manoukian R, Yeh R, "et al." |title=Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. |journal=Blood |volume=100 |issue= 7 |pages= 2330–40 |year= 2002 |pmid= 12239140 |doi= 10.1182/blood-2002-01-0012
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Létuvé S, Lajoie-Kadoch S, Audusseau S, "et al." |title=IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. |journal=J. Allergy Clin. Immunol. |volume=117 |issue= 3 |pages= 590–6 |year= 2006 |pmid= 16522458 |doi= 10.1016/j.jaci.2005.10.025
*cite journal | author=Tamachi T, Maezawa Y, Ikeda K, "et al." |title=IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. |journal=J. Allergy Clin. Immunol. |volume=118 |issue= 3 |pages= 606–14 |year= 2006 |pmid= 16950278 |doi= 10.1016/j.jaci.2006.04.051
*cite journal | author=Wang YH, Angkasekwinai P, Lu N, "et al." |title=IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. |journal=J. Exp. Med. |volume=204 |issue= 8 |pages= 1837–47 |year= 2007 |pmid= 17635955 |doi= 10.1084/jem.20070406PBB_Controls
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