NAPG

N-ethylmaleimide-sensitive factor attachment protein, gamma
Identifiers
Symbols	NAPG; GAMMASNAP
External IDs	OMIM: 603216 MGI: 104561 HomoloGene: 2838 GeneCards: NAPG Gene
Gene Ontology Molecular function • protein binding Cellular component • membrane fraction • mitochondrion • membrane Biological process • protein complex assembly • intracellular protein transport • intra-Golgi vesicle-mediated transport • cellular membrane fusion • vesicle-mediated transport • protein stabilization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8774	108123
Ensembl	ENSG00000134265	ENSMUSG00000024581
UniProt	Q99747	Q8C1T5
RefSeq (mRNA)	NM_003826	NM_028017.1
RefSeq (protein)	NP_003817	NP_082293.1
Location (UCSC)	Chr 18: 10.53 – 10.55 Mb	Chr 18: 63.14 – 63.16 Mb
PubMed search	[1]	[2]

Gamma-soluble NSF attachment protein is a protein that in humans is encoded by the NAPG gene.^[1][2]

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[2]

References

1. ^ Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood 90 (4): 1490–500. PMID 9269766. 
2. ^ ^{a b} "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774. 

Further reading

• Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion.". J. Cell Biol. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2289450. 
• Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes.". J. Biol. Chem. 267 (17): 12239–43. PMID 1601890. 
• Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform.". Nature 362 (6418): 353–5. doi:10.1038/362353a0. PMID 8455721. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes.". Endocrinology 138 (6): 2391–7. doi:10.1210/en.138.6.2391. PMID 9165027. 
• Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome.". J. Cell. Sci. 113 ( Pt 6): 997–1008. PMID 10683148. 
• Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria.". J. Biol. Chem. 276 (16): 13127–35. doi:10.1074/jbc.M009424200. PMID 11278501. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP.". J. Biol. Chem. 278 (15): 13531–8. doi:10.1074/jbc.M213205200. PMID 12554740. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.