ST3GAL5

ST3GAL5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5, also known as ST3GAL5, is a human gene.cite web | title = Entrez Gene: ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8869| accessdate = ]

PBB_Summary
section_title =
summary_text = Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8869| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ishii A, Ohta M, Watanabe Y, "et al." |title=Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31652–5 |year= 1998 |pmid= 9822625 |doi=
*cite journal | author=Fukumoto S, Miyazaki H, Goto G, "et al." |title=Expression cloning of mouse cDNA of CMP-NeuAc:Lactosylceramide alpha2,3-sialyltransferase, an enzyme that initiates the synthesis of gangliosides. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9271–6 |year= 1999 |pmid= 10092602 |doi=
*cite journal | author=Kapitonov D, Bieberich E, Yu RK |title=Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. |journal=Glycoconj. J. |volume=16 |issue= 7 |pages= 337–50 |year= 2000 |pmid= 10619706 |doi=
*cite journal | author=Allende ML, Li J, Darling DS, "et al." |title=Evidence supporting a late Golgi location for lactosylceramide to ganglioside GM3 conversion. |journal=Glycobiology |volume=10 |issue= 10 |pages= 1025–32 |year= 2000 |pmid= 11030748 |doi=
*cite journal | author=Kim KW, Kim SW, Min KS, "et al." |title=Genomic structure of human GM3 synthase gene (hST3Gal V) and identification of mRNA isoforms in the 5'-untranslated region. |journal=Gene |volume=273 |issue= 2 |pages= 163–71 |year= 2001 |pmid= 11595162 |doi=
*cite journal | author=Kim SW, Lee SH, Kim KS, "et al." |title=Isolation and characterization of the promoter region of the human GM3 synthase gene. |journal=Biochim. Biophys. Acta |volume=1578 |issue= 1-3 |pages= 84–9 |year= 2002 |pmid= 12393190 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zeng G, Gao L, Xia T, "et al." |title=Characterization of the 5'-flanking fragment of the human GM3-synthase gene. |journal=Biochim. Biophys. Acta |volume=1625 |issue= 1 |pages= 30–5 |year= 2003 |pmid= 12527423 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Chung TW, Choi HJ, Lee YC, Kim CH |title=Molecular mechanism for transcriptional activation of ganglioside GM3 synthase and its function in differentiation of HL-60 cells. |journal=Glycobiology |volume=15 |issue= 3 |pages= 233–44 |year= 2005 |pmid= 15385432 |doi= 10.1093/glycob/cwh156
*cite journal | author=Simpson MA, Cross H, Proukakis C, "et al." |title=Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase. |journal=Nat. Genet. |volume=36 |issue= 11 |pages= 1225–9 |year= 2004 |pmid= 15502825 |doi= 10.1038/ng1460
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Berselli P, Zava S, Sottocornola E, "et al." |title=Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein. |journal=Biochim. Biophys. Acta |volume=1759 |issue= 7 |pages= 348–58 |year= 2006 |pmid= 16934889 |doi= 10.1016/j.bbaexp.2006.07.001

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”