WNK4

WNK lysine deficient protein kinase 4, also known as WNK4, is a human gene.cite web | title = Entrez Gene: WNK4 WNK lysine deficient protein kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65266| accessdate = ]

PBB_Summary
section_title =
summary_text = The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron. [supplied by OMIM] cite web | title = Entrez Gene: WNK4 WNK lysine deficient protein kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65266| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Subramanya AR, Yang CL, McCormick JA, Ellison DH |title=WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 630–4 |year= 2006 |pmid= 16820787 |doi= 10.1038/sj.ki.5001634
*cite journal | author=Peng JB, Warnock DG |title=WNK4-mediated regulation of renal ion transport proteins. |journal=Am. J. Physiol. Renal Physiol. |volume=293 |issue= 4 |pages= F961–73 |year= 2007 |pmid= 17634397 |doi= 10.1152/ajprenal.00192.2007
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Wilson FH, Disse-Nicodème S, Choate KA, "et al." |title=Human hypertension caused by mutations in WNK kinases. |journal=Science |volume=293 |issue= 5532 |pages= 1107–12 |year= 2001 |pmid= 11498583 |doi= 10.1126/science.1062844
*cite journal | author=Veríssimo F, Jordan P |title=WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. |journal=Oncogene |volume=20 |issue= 39 |pages= 5562–9 |year= 2001 |pmid= 11571656 |doi= 10.1038/sj.onc.1204726
*cite journal | author=Wilson FH, Kahle KT, Sabath E, "et al." |title=Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 680–4 |year= 2003 |pmid= 12515852 |doi= 10.1073/pnas.242735399
*cite journal | author=Erlich PM, Cui J, Chazaro I, "et al." |title=Genetic variants of WNK4 in whites and African Americans with hypertension. |journal=Hypertension |volume=41 |issue= 6 |pages= 1191–5 |year= 2003 |pmid= 12719438 |doi= 10.1161/01.HYP.0000070025.30572.91
*cite journal | author=Piechotta K, Garbarini N, England R, Delpire E |title=Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52848–56 |year= 2004 |pmid= 14563843 |doi= 10.1074/jbc.M309436200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kahle KT, Gimenez I, Hassan H, "et al." |title=WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 7 |pages= 2064–9 |year= 2004 |pmid= 14769928 |doi= 10.1073/pnas.0308434100
*cite journal | author=Yamauchi K, Rai T, Kobayashi K, "et al." |title=Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4690–4 |year= 2004 |pmid= 15070779 |doi= 10.1073/pnas.0306924101
*cite journal | author=Kamide K, Takiuchi S, Tanaka C, "et al." |title=Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes. |journal=Am. J. Hypertens. |volume=17 |issue= 5 Pt 1 |pages= 446–9 |year= 2004 |pmid= 15110905 |doi= 10.1016/j.amjhyper.2003.12.020
*cite journal | author=Mayan H, Munter G, Shaharabany M, "et al." |title=Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 8 |pages= 4025–30 |year= 2004 |pmid= 15292344 |doi= 10.1210/jc.2004-0037
*cite journal | author=Fu Y, Subramanya A, Rozansky D, Cohen DM |title=WNK kinases influence TRPV4 channel function and localization. |journal=Am. J. Physiol. Renal Physiol. |volume=290 |issue= 6 |pages= F1305–14 |year= 2006 |pmid= 16403833 |doi= 10.1152/ajprenal.00391.2005
*cite journal | author=Cai H, Cebotaru V, Wang YH, "et al." |title=WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. |journal=Kidney Int. |volume=69 |issue= 12 |pages= 2162–70 |year= 2006 |pmid= 16688122 |doi= 10.1038/sj.ki.5000333
*cite journal | author=Jiang Y, Ferguson WB, Peng JB |title=WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. |journal=Am. J. Physiol. Renal Physiol. |volume=292 |issue= 2 |pages= F545–54 |year= 2007 |pmid= 17018846 |doi= 10.1152/ajprenal.00187.2006
*cite journal | author=Ring AM, Leng Q, Rinehart J, "et al." |title=An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4025–9 |year= 2007 |pmid= 17360471 |doi= 10.1073/pnas.0611728104

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