NAGK

N-acetylglucosamine kinase
PDB rendering based on 2ch5.
Available structures PDB 2CH5, 2CH6
Identifiers
Symbols	NAGK; GNK; HSA242910
External IDs	OMIM: 606828 MGI: 1860418 HomoloGene: 9720 GeneCards: NAGK Gene
EC number	2.7.1.59
Gene Ontology Molecular function • nucleotide binding • protein binding • ATP binding • N-acylmannosamine kinase activity • kinase activity • transferase activity • N-acetylglucosamine kinase activity Cellular component • soluble fraction Biological process • N-acetylglucosamine metabolic process • N-acetylmannosamine metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55577	56174
Ensembl	ENSG00000124357	ENSMUSG00000034744
UniProt	Q9UJ70	Q3U2G9
RefSeq (mRNA)	NM_017567	NM_019542
RefSeq (protein)	NP_060037	NP_062415
Location (UCSC)	Chr 2: 71.29 – 71.31 Mb	Chr 6: 83.74 – 83.75 Mb
PubMed search	[1]	[2]

N-acetyl-D-glucosamine kinase is an enzyme that in humans is encoded by the NAGK gene.^[1][2]

N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals.[supplied by OMIM]^[2]

Interactions

NAGK has been shown to interact with STK16^[3] and LNX1.^[4]

References

1. ^ Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W (Jul 2000). "Molecular cloning and characterization of murine and human N-acetylglucosamine kinase". Eur J Biochem 267 (11): 3301–8. doi:10.1046/j.1432-1327.2000.01360.x. PMID 10824116. 
2. ^ ^{a b} "Entrez Gene: NAGK N-acetylglucosamine kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55577. 
3. ^ Ligos, Jose Manuel; de Lera Teresa Laín, Hinderlich Stephan, Guinea Bárbara, Sánchez Luis, Roca Ramón, Valencia Alfonso, Bernad Antonio (Feb. 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". J. Biol. Chem. (United States) 277 (8): 6333–43. doi:10.1074/jbc.M105766200. ISSN 0021-9258. PMID 11741987. 
4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Weidanz JA, Campbell P, Moore D, et al. (1997). "N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum". Br. J. Haematol. 95 (4): 645–53. doi:10.1046/j.1365-2141.1996.d01-1955.x. PMID 8982040. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Lowes W, Walker M, Alberti KG, Agius L (1998). "Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis". Biochim. Biophys. Acta 1379 (1): 134–42. PMID 9468341. 
• Ligos JM, de Lera TL, Hinderlich S, et al. (2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". J. Biol. Chem. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987. 
• Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets". Proteomics 2 (6): 642–8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Sparks SE, Ciccone C, Lalor M, et al. (2006). "Use of a cell-free system to determine UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities in human hereditary inclusion body myopathy". Glycobiology 15 (11): 1102–10. doi:10.1093/glycob/cwi100. PMID 15987957. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Weihofen WA, Berger M, Chen H, et al. (2007). "Structures of human N-Acetylglucosamine kinase in two complexes with N-Acetylglucosamine and with ADP/glucose: insights into substrate specificity and regulation". J. Mol. Biol. 364 (3): 388–99. doi:10.1016/j.jmb.2006.08.085. PMID 17010375.