NGFRAP1

Nerve growth factor receptor (TNFRSF16) associated protein 1
Identifiers
Symbols	NGFRAP1; BEX3; Bex; DXS6984E; HGR74; NADE
External IDs	OMIM: 300361 MGI: 1338016 HomoloGene: 7642 GeneCards: NGFRAP1 Gene
Gene Ontology Molecular function • death receptor binding • protein binding • caspase regulator activity • metal ion binding Cellular component • nucleus • cytoplasm • cytosol Biological process • apoptosis • multicellular organismal development • induction of apoptosis by extracellular signals • induction of apoptosis via death domain receptors • regulation of caspase activity • nerve growth factor receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27018	12070
Ensembl	ENSG00000166681	ENSMUSG00000046432
UniProt	Q00994	Q9WTZ9
RefSeq (mRNA)	NM_014380.1	XM_975991
RefSeq (protein)	NP_055195.1	XP_981085
Location (UCSC)	Chr X: 102.63 – 102.63 Mb	Chr X: 132.8 – 132.81 Mb
PubMed search	[1]	[2]

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.^[1][2][3]

Interactions

NGFRAP1 has been shown to interact with YWHAE^[4] and Low affinity nerve growth factor receptor.^[1]

References

1. ^ ^{a b} Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J Biol Chem 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727. 
2. ^ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol 9 (7): 479–85. doi:10.1089/dna.1990.9.479. PMID 2171551. 
3. ^ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27018. 
4. ^ Kimura, M T; Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato T A (May. 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. (United States) 276 (20): 17291–300. doi:10.1074/jbc.M005453200. ISSN 0021-9258. PMID 11278287. 

Further reading

• Auffray C, Behar G, Bois F et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816. 
• Ye X, Mehlen P, Rabizadeh S et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
• Irie S, Hachiya T, Rabizadeh S et al. (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233. 
• Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738. 
• Kimura MT, Irie S, Shoji-Hoshino S et al. (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287. 
• Mukai J, Shoji S, Kimura MT et al. (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tong X, Xie D, Roth W et al. (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. PMID 12739005. 
• Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286. 
• Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Yu Y, Wang J, Yuan H et al. (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077. 
• Yasui S, Tsuzaki K, Ninomiya H et al. (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.