YWHAE

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, also known as YWHAE, is a human gene.

PBB_Summary
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summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. [cite web | title = Entrez Gene: YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7531| accessdate = ]

ee also

* 14-3-3 protein

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Jones DH, Ley S, Aitken A |title=Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins. |journal=FEBS Lett. |volume=368 |issue= 1 |pages= 55–8 |year= 1995 |pmid= 7615088 |doi=
*cite journal | author=Conklin DS, Galaktionov K, Beach D |title=14-3-3 proteins associate with cdc25 phosphatases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7892–6 |year= 1995 |pmid= 7644510 |doi=
*cite journal | author=Jin DY, Lyu MS, Kozak CA, Jeang KT |title=Function of 14-3-3 proteins. |journal=Nature |volume=382 |issue= 6589 |pages= 308 |year= 1996 |pmid= 8684458 |doi= 10.1038/382308a0
*cite journal | author=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029–34 |year= 1996 |pmid= 8702721 |doi=
*cite journal | author=Chong SS, Tanigami A, Roschke AV, Ledbetter DH |title=14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. |journal=Genome Res. |volume=6 |issue= 8 |pages= 735–41 |year= 1997 |pmid= 8858348 |doi=
*cite journal | author=Craparo A, Freund R, Gustafson TA |title=14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11663–9 |year= 1997 |pmid= 9111084 |doi=
*cite journal | author=Han L, Wong D, Dhaka A, "et al." |title=Protein binding and signaling properties of RIN1 suggest a unique effector function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 4954–9 |year= 1997 |pmid= 9144171 |doi=
*cite journal | author=Ogihara T, Isobe T, Ichimura T, "et al." |title=14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25267–74 |year= 1997 |pmid= 9312143 |doi=
*cite journal | author=Hsu SY, Kaipia A, Zhu L, Hsueh AJ |title=Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. |journal=Mol. Endocrinol. |volume=11 |issue= 12 |pages= 1858–67 |year= 1997 |pmid= 9369453 |doi=
*cite journal | author=Luk SC, Garcia-Barcelo M, Tsui SK, "et al." |title=Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 105–6 |year= 1997 |pmid= 9371399 |doi=
*cite journal | author=Nagata K, Puls A, Futter C, "et al." |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149
*cite journal | author=Fanger GR, Widmann C, Porter AC, "et al." |title=14-3-3 proteins interact with specific MEK kinases. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3476–83 |year= 1998 |pmid= 9452471 |doi=
*cite journal | author=Ku NO, Liao J, Omary MB |title=Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. |journal=EMBO J. |volume=17 |issue= 7 |pages= 1892–906 |year= 1998 |pmid= 9524113 |doi= 10.1093/emboj/17.7.1892
*cite journal | author=Luk SC, Ngai SM, Tsui SK, "et al." |title=In vivo and in vitro association of 14-3-3 epsilon isoform with calmodulin: implication for signal transduction and cell proliferation. |journal=J. Cell. Biochem. |volume=73 |issue= 1 |pages= 31–5 |year= 1999 |pmid= 10088721 |doi=
*cite journal | author=Ostrerova N, Petrucelli L, Farrer M, "et al." |title=alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. |journal=J. Neurosci. |volume=19 |issue= 14 |pages= 5782–91 |year= 1999 |pmid= 10407019 |doi=
*cite journal | author=Finlin BS, Andres DA |title=Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 2 |pages= 401–12 |year= 1999 |pmid= 10441394 |doi= 10.1006/abbi.1999.1316
*cite journal | author=Dorner C, Ullrich A, Häring HU, Lammers R |title=The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family. |journal=J. Biol. Chem. |volume=274 |issue= 47 |pages= 33654–60 |year= 1999 |pmid= 10559254 |doi=
*cite journal | author=Aoki H, Hayashi J, Moriyama M, "et al." |title=Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. |journal=J. Virol. |volume=74 |issue= 4 |pages= 1736–41 |year= 2000 |pmid= 10644344 |doi=

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