NDUFA13

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Identifiers
Symbols	NDUFA13; B16.6; CDA016; FLJ58045; FLJ59191; GRIM-19; GRIM19
External IDs	OMIM: 609435 MGI: 1914434 HomoloGene: 41083 GeneCards: NDUFA13 Gene
Gene Ontology Molecular function • NADH dehydrogenase activity • protein binding • ATP binding • NADH dehydrogenase (ubiquinone) activity Cellular component • nucleus • nucleoplasm • cytoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain • mitochondrial respiratory chain complex I • membrane • integral to membrane • mitochondrial membrane Biological process • protein import into nucleus • transport • apoptosis • induction of apoptosis • induction of apoptosis by extracellular signals • negative regulation of translation • respiratory electron transport chain • apoptotic nuclear change • negative regulation of cell growth • negative regulation of cell growth • negative regulation of transcription, DNA-dependent • reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51079	67184
Ensembl	ENSG00000186010	ENSMUSG00000036199
UniProt	Q9P0J0	Q9ERS2
RefSeq (mRNA)	NM_015965	NM_023312.2
RefSeq (protein)	NP_057049	NP_075801.1
Location (UCSC)	Chr 19: 19.63 – 19.65 Mb	Chr 8: 72.42 – 72.43 Mb
PubMed search	[1]	[2]

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 is an enzyme that in humans is encoded by the NDUFA13 gene.^[1][2][3][4]

Interactions

NDUFA13 has been shown to interact with STAT3.^[5]

References

1. ^ Hirst J, Carroll J, Fearnley IM, Shannon RJ, Walker JE (Jul 2003). "The nuclear encoded subunits of complex I from bovine heart mitochondria". Biochim Biophys Acta 1604 (3): 135–50. doi:10.1016/S0005-2728(03)00059-8. PMID 12837546. 
2. ^ Angell JE, Lindner DJ, Shapiro PS, Hofmann ER, Kalvakolanu DV (Nov 2000). "Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach". J Biol Chem 275 (43): 33416–26. doi:10.1074/jbc.M003929200. PMID 10924506. 
3. ^ Huang G, Lu H, Hao A, Ng DC, Ponniah S, Guo K, Lufei C, Zeng Q, Cao X (Sep 2004). "GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I". Mol Cell Biol 24 (19): 8447–56. doi:10.1128/MCB.24.19.8447-8456.2004. PMC 516758. PMID 15367666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=516758. 
4. ^ "Entrez Gene: NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51079. 
5. ^ Zhang, Jun; Yang Jinbo, Roy Sanjit K, Tininini Silvia, Hu Jiadi, Bromberg Jacqueline F, Poli Valeria, Stark George R, Kalvakolanu Dhananjaya V (Aug. 2003). "The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (16): 9342–7. doi:10.1073/pnas.1633516100. ISSN 0027-8424. PMC 170920. PMID 12867595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=170920. 

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310876. 
• Chidambaram NV, Angell JE, Ling W, et al. (2000). "Chromosomal localization of human GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death.". J. Interferon Cytokine Res. 20 (7): 661–5. doi:10.1089/107999000414844. PMID 10926209. 
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901. 
• Fearnley IM, Carroll J, Shannon RJ, et al. (2001). "GRIM-19, a cell death regulatory gene product, is a subunit of bovine mitochondrial NADH:ubiquinone oxidoreductase (complex I).". J. Biol. Chem. 276 (42): 38345–8. doi:10.1074/jbc.C100444200. PMID 11522775. 
• Seo T, Lee D, Shim YS, et al. (2002). "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.". J. Virol. 76 (17): 8797–807. doi:10.1128/JVI.76.17.8797-8807.2002. PMC 136415. PMID 12163600. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136415. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Murray J, Zhang B, Taylor SW, et al. (2003). "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.". J. Biol. Chem. 278 (16): 13619–22. doi:10.1074/jbc.C300064200. PMID 12611891. 
• Lufei C, Ma J, Huang G, et al. (2003). "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction.". EMBO J. 22 (6): 1325–35. doi:10.1093/emboj/cdg135. PMC 151078. PMID 12628925. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151078. 
• Zhang J, Yang J, Roy SK, et al. (2003). "The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9342–7. doi:10.1073/pnas.1633516100. PMC 170920. PMID 12867595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=170920. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Barnich N, Hisamatsu T, Aguirre JE, et al. (2005). "GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.". J. Biol. Chem. 280 (19): 19021–6. doi:10.1074/jbc.M413776200. PMID 15753091. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Huang G, Chen Y, Lu H, Cao X (2007). "Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death.". Cell Death Differ. 14 (2): 327–37. doi:10.1038/sj.cdd.4402004. PMID 16826196. 
• Vogel RO, Dieteren CE, van den Heuvel LP, et al. (2007). "Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.". J. Biol. Chem. 282 (10): 7582–90. doi:10.1074/jbc.M609410200. PMID 17209039.