NUDC

Nuclear distribution gene C homolog (A. nidulans)
PDB rendering based on 2cr0.
Available structures PDB 2cr0
Identifiers
Symbols	NUDC; HNUDC; MNUDC; NPD011
External IDs	OMIM: 610325 MGI: 106014 HomoloGene: 4812 GeneCards: NUDC Gene
Gene Ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • cytosol • cytoskeleton • microtubule Biological process • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • cytokinesis • nuclear migration • multicellular organismal development • cell proliferation • response to peptide hormone stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10726	18221
Ensembl	ENSG00000090273	ENSMUSG00000028851
UniProt	Q9Y266	O35685
RefSeq (mRNA)	NM_006600	NM_010948.3
RefSeq (protein)	NP_006591	NP_035078.1
Location (UCSC)	Chr 1: 27.23 – 27.27 Mb	Chr 4: 133.09 – 133.1 Mb
PubMed search	[1]	[2]

Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene.^[1]

Interactions

NUDC has been shown to interact with PLK1^[2] and PAFAH1B1.^[3]

References

1. ^ "Entrez Gene: NUDC nuclear distribution gene C homolog (A. nidulans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10726. 
2. ^ Zhou, Tianhua; Aumais Jonathan P, Liu Xiaoqi, Yu-Lee Li-Yuan, Erikson Raymond L (Jul. 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Dev. Cell (United States) 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. ISSN 1534-5807. PMID 12852857. 
3. ^ Morris, S M; Albrecht U, Reiner O, Eichele G, Yu-Lee L Y (May. 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Curr. Biol. (ENGLAND) 8 (10): 603–6. doi:10.1016/S0960-9822(98)70232-5. ISSN 0960-9822. PMID 9601647. 

Further reading

• Morris SM, Albrecht U, Reiner O, et al. (1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC.". Curr. Biol. 8 (10): 603–6. doi:10.1016/S0960-9822(98)70232-5. PMID 9601647. 
• Miller BA, Zhang MY, Gocke CD, et al. (1999). "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis.". Exp. Hematol. 27 (4): 742–50. doi:10.1016/S0301-472X(98)00074-5. PMID 10210332. 
• Matsumoto N, Ledbetter DH (1999). "Molecular cloning and characterization of the human NUDC gene.". Hum. Genet. 104 (6): 498–504. doi:10.1007/s004390050994. PMID 10453739. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Aumais JP, Tunstead JR, McNeil RS, et al. (2002). "NudC associates with Lis1 and the dynein motor at the leading pole of neurons.". J. Neurosci. 21 (24): RC187. PMID 11734602. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Aumais JP, Williams SN, Luo W, et al. (2004). "Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.". J. Cell. Sci. 116 (Pt 10): 1991–2003. doi:10.1242/jcs.00412. PMID 12679384. 
• Zhou T, Aumais JP, Liu X, et al. (2003). "A role for Plk1 phosphorylation of NudC in cytokinesis.". Dev. Cell 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. PMID 12852857. 
• Lin SH, Nishino M, Luo W, et al. (2004). "Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein.". Oncogene 23 (14): 2499–506. doi:10.1038/sj.onc.1207343. PMID 14676831. 
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Pan RM, Yang Y, Wei MX, et al. (2006). "A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl).". J. Cell. Biochem. 96 (4): 741–50. doi:10.1002/jcb.20573. PMID 16088917. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Nishino M, Kurasawa Y, Evans R, et al. (2006). "NudC is required for Plk1 targeting to the kinetochore and chromosome congression.". Curr. Biol. 16 (14): 1414–21. doi:10.1016/j.cub.2006.05.052. PMID 16860740. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.