NTHL1

Nth endonuclease III-like 1 (E. coli)
Identifiers
Symbols	NTHL1; NTH1; OCTS3
External IDs	OMIM: 602656 MGI: 1313275 HomoloGene: 1897 GeneCards: NTHL1 Gene
EC number	4.2.99.18
Gene Ontology Molecular function • oxidized pyrimidine base lesion DNA N-glycosylase activity • oxidized pyrimidine base lesion DNA N-glycosylase activity • DNA binding • double-stranded DNA binding • DNA-(apurinic or apyrimidinic site) lyase activity • endonuclease activity • protein binding • hydrolase activity, acting on glycosyl bonds • lyase activity • DNA N-glycosylase activity • metal ion binding • 4 iron, 4 sulfur cluster binding Cellular component • nucleus • nucleoplasm • nucleoplasm Biological process • DNA repair • base-excision repair • base-excision repair, AP site formation • base-excision repair, AP site formation • nucleotide-excision repair, DNA incision, 5'-to lesion • depyrimidination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4913	18207
Ensembl	ENSG00000065057	ENSMUSG00000041429
UniProt	P78549	O35980
RefSeq (mRNA)	NM_002528	NM_008743.2
RefSeq (protein)	NP_002519	NP_032769.2
Location (UCSC)	Chr 16: 2.09 – 2.1 Mb	Chr 17: 24.77 – 24.78 Mb
PubMed search	[1]	[2]

Endonuclease III-like protein 1 is an enzyme that in humans is encoded by the NTHL1 gene.^[1][2][3]

References

1. ^ Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW (Apr 1997). "Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III". J Biol Chem 272 (10): 6733–40. doi:10.1074/jbc.272.10.6733. PMID 9045706. 
2. ^ Aspinwall R, Rothwell DG, Roldan-Arjona T, Anselmino C, Ward CJ, Cheadle JP, Sampson JR, Lindahl T, Harris PC, Hickson ID (Feb 1997). "Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III". Proc Natl Acad Sci U S A 94 (1): 109–14. doi:10.1073/pnas.94.1.109. PMC 19249. PMID 8990169. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19249. 
3. ^ "Entrez Gene: NTHL1 nth endonuclease III-like 1 (E. coli)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4913. 

Further reading

• Hilbert TP, Boorstein RJ, Kung HC, et al. (1996). "Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide.". Biochemistry 35 (8): 2505–11. doi:10.1021/bi952516e. PMID 8611553. 
• Ikeda S, Biswas T, Roy R, et al. (1998). "Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue.". J. Biol. Chem. 273 (34): 21585–93. doi:10.1074/jbc.273.34.21585. PMID 9705289. 
• Sarker AH, Ikeda S, Nakano H, et al. (1999). "Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III.". J. Mol. Biol. 282 (4): 761–74. doi:10.1006/jmbi.1998.2042. PMID 9743625. 
• Imai K, Sarker AH, Akiyama K, et al. (1999). "Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.". Gene 222 (2): 287–95. doi:10.1016/S0378-1119(98)00485-5. PMID 9831664. 
• Bessho T (1999). "Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase.". Nucleic Acids Res. 27 (4): 979–83. doi:10.1093/nar/27.4.979. PMC 148276. PMID 9927729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148276. 
• Luna L, Bjørås M, Hoff E, et al. (2000). "Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA.". Mutat. Res. 460 (2): 95–104. PMID 10882850. 
• Matsumoto Y, Zhang QM, Takao M, et al. (2002). "Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.". Nucleic Acids Res. 29 (9): 1975–81. doi:10.1093/nar/29.9.1975. PMC 37258. PMID 11328882. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=37258. 
• Miyabe I, Zhang QM, Kino K, et al. (2002). "Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein.". Nucleic Acids Res. 30 (15): 3443–8. doi:10.1093/nar/gkf460. PMC 137084. PMID 12140329. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137084. 
• Liu X, Roy R (2002). "Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1).". J. Mol. Biol. 321 (2): 265–76. doi:10.1016/S0022-2836(02)00623-X. PMID 12144783. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Marenstein DR, Chan MK, Altamirano A, et al. (2003). "Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.". J. Biol. Chem. 278 (11): 9005–12. doi:10.1074/jbc.M212168200. PMID 12519758. 
• Ikeda S, Kohmoto T, Tabata R, Seki Y (2003). "Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals.". DNA Repair (Amst.) 1 (10): 847–54. doi:10.1016/S1568-7864(02)00145-3. PMID 12531031. 
• Liu X, Choudhury S, Roy R (2004). "In vitro and in vivo dimerization of human endonuclease III stimulates its activity.". J. Biol. Chem. 278 (50): 50061–9. doi:10.1074/jbc.M309997200. PMID 14522981. 
• Katafuchi A, Nakano T, Masaoka A, et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554. 
• Wiederhold L, Leppard JB, Kedar P, et al. (2004). "AP endonuclease-independent DNA base excision repair in human cells.". Mol. Cell 15 (2): 209–20. doi:10.1016/j.molcel.2004.06.003. PMID 15260972. 
• Oyama M, Wakasugi M, Hama T, et al. (2004). "Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen.". Biochem. Biophys. Res. Commun. 321 (1): 183–91. doi:10.1016/j.bbrc.2004.06.136. PMID 15358233. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Zhang QM, Yonekura S, Takao M, et al. (2005). "DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.". DNA Repair (Amst.) 4 (1): 71–9. doi:10.1016/j.dnarep.2004.08.002. PMID 15533839.