PDLIM5

PDZ and LIM domain 5
PDB rendering based on 1wf7.
Available structures PDB 2DAR, 2UZC
Identifiers
Symbols	PDLIM5; ENH; ENH1; LIM
External IDs	OMIM: 605904 MGI: 1927489 HomoloGene: 21289 GeneCards: PDLIM5 Gene
Gene Ontology Molecular function • actin binding • protein kinase C binding • zinc ion binding • actinin binding • metal ion binding • protein N-terminus binding Cellular component • membrane fraction • cytoplasm • cytosol • plasma membrane • postsynaptic density • actin cytoskeleton • synaptosome • Z disc • cell junction • synapse • postsynaptic membrane Biological process • regulation of synaptogenesis • regulation of dendritic spine morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10611	56376
Ensembl	ENSG00000163110	ENSMUSG00000028273
UniProt	Q96HC4	n/a
RefSeq (mRNA)	NM_001011513.2	NM_019808
RefSeq (protein)	NP_001011513.2	NP_062782
Location (UCSC)	Chr 4: 95.37 – 95.59 Mb	Chr 3: 141.9 – 142.06 Mb
PubMed search	[1]	[2]

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.^[1][2]

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.^[2]

Interactions

PDLIM5 has been shown to interact with PRKCB1.^[3]

References

1. ^ Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (Sep 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770. 
2. ^ ^{a b} "Entrez Gene: PDLIM5 PDZ and LIM domain 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10611. 
3. ^ Kuroda, S; Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill G N, Kikkawa U (Dec. 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. (UNITED STATES) 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095. 

Further reading

• Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Kuroda S, Tokunaga C, Kiyohara Y et al. (1997). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095. 
• Ueki N, Seki N, Yano K et al. (1999). "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)". J. Hum. Genet. 44 (4): 256–60. doi:10.1007/s100380050155. PMID 10429367. 
• Nakagawa N, Hoshijima M, Oyasu M et al. (2000). "ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain". Biochem. Biophys. Res. Commun. 272 (2): 505–12. doi:10.1006/bbrc.2000.2787. PMID 10833443. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Maeno-Hikichi Y, Chang S, Matsumura K et al. (2003). "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nat. Neurosci. 6 (5): 468–75. doi:10.1038/nn1041. PMID 12665800. 
• Iwamoto K, Kakiuchi C, Bundo M et al. (2004). "Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders". Mol. Psychiatry 9 (4): 406–16. doi:10.1038/sj.mp.4001437. PMID 14743183. 
• Petroziello J, Yamane A, Westendorf L et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068. 
• Iwamoto K, Bundo M, Washizuka S et al. (2004). "Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia". J. Hum. Genet. 49 (5): 227–31. doi:10.1007/s10038-004-0136-5. PMID 15362566. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930. 
• Niederländer N, Fayein NA, Auffray C, Pomiès P (2005). "Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 325 (4): 1304–11. doi:10.1016/j.bbrc.2004.10.178. PMID 15555569. 
• Kato T, Iwayama Y, Kakiuchi C et al. (2005). "Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia". Mol. Psychiatry 10 (11): 1045–55. doi:10.1038/sj.mp.4001719. PMID 16044170. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Horiuchi Y, Arai M, Niizato K et al. (2006). "A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia". Biol. Psychiatry 59 (5): 434–9. doi:10.1016/j.biopsych.2005.07.041. PMID 16213469.