- RAD51C
RAD51 homolog C (S. cerevisiae), also known as RAD51C, is a human
gene .PBB_Summary
section_title =
summary_text = This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.cite web | title = Entrez Gene: RAD51C RAD51 homolog C (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5889| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Dosanjh MK, Collins DW, Fan W, "et al." |title=Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. |journal=Nucleic Acids Res. |volume=26 |issue= 5 |pages= 1179–84 |year= 1998 |pmid= 9469824 |doi=10.1093/nar/26.5.1179
*cite journal | author=Schild D, Lio YC, Collins DW, "et al." |title=Evidence for simultaneous protein interactions between human Rad51 paralogs. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16443–9 |year= 2000 |pmid= 10749867 |doi= 10.1074/jbc.M001473200
*cite journal | author=Avela K, Lipsanen-Nyman M, Idänheimo N, "et al." |title=Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 298–301 |year= 2000 |pmid= 10888877 |doi= 10.1038/77053
*cite journal | author=Bärlund M, Monni O, Kononen J, "et al." |title=Multiple genes at 17q23 undergo amplification and overexpression in breast cancer. |journal=Cancer Res. |volume=60 |issue= 19 |pages= 5340–4 |year= 2000 |pmid= 11034067 |doi=
*cite journal | author=Wu GJ, Sinclair CS, Paape J, "et al." |title=17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes. |journal=Cancer Res. |volume=60 |issue= 19 |pages= 5371–5 |year= 2000 |pmid= 11034073 |doi=
*cite journal | author=Kurumizaka H, Ikawa S, Nakada M, "et al." |title=Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 10 |pages= 5538–43 |year= 2001 |pmid= 11331762 |doi= 10.1073/pnas.091603098
*cite journal | author=Leasure CS, Chandler J, Gilbert DJ, "et al." |title=Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. |journal=Gene |volume=271 |issue= 1 |pages= 59–67 |year= 2001 |pmid= 11410366 |doi=10.1016/S0378-1119(01)00498-X
*cite journal | author=Masson JY, Stasiak AZ, Stasiak A, "et al." |title=Complex formation by the human RAD51C and XRCC3 recombination repair proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8440–6 |year= 2001 |pmid= 11459987 |doi= 10.1073/pnas.111005698
*cite journal | author=Miller KA, Yoshikawa DM, McConnell IR, "et al." |title=RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8406–11 |year= 2002 |pmid= 11744692 |doi= 10.1074/jbc.M108306200
*cite journal | author=Masson JY, Tarsounas MC, Stasiak AZ, "et al." |title=Identification and purification of two distinct complexes containing the five RAD51 paralogs. |journal=Genes Dev. |volume=15 |issue= 24 |pages= 3296–307 |year= 2002 |pmid= 11751635 |doi= 10.1101/gad.947001
*cite journal | author=Sigurdsson S, Van Komen S, Bussen W, "et al." |title=Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. |journal=Genes Dev. |volume=15 |issue= 24 |pages= 3308–18 |year= 2002 |pmid= 11751636 |doi= 10.1101/gad.935501
*cite journal | author=Wiese C, Collins DW, Albala JS, "et al." |title=Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1001–8 |year= 2002 |pmid= 11842112 |doi=10.1093/nar/30.4.1001
*cite journal | author=Liu N, Schild D, Thelen MP, Thompson LH |title=Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1009–15 |year= 2002 |pmid= 11842113 |doi=10.1093/nar/30.4.1009
*cite journal | author=Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ |title=Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1. |journal=Oncogene |volume=21 |issue= 32 |pages= 5002–5 |year= 2002 |pmid= 12118380 |doi= 10.1038/sj.onc.1205656
*cite journal | author=Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ |title=Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2469–78 |year= 2003 |pmid= 12427746 |doi= 10.1074/jbc.M211038200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=French CA, Tambini CE, Thacker J |title=Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45445–50 |year= 2003 |pmid= 12966089 |doi= 10.1074/jbc.M308621200
*cite journal | author=Braybrooke JP, Li JL, Wu L, "et al." |title=Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48357–66 |year= 2004 |pmid= 12975363 |doi= 10.1074/jbc.M308838200
*cite journal | author=Miller KA, Sawicka D, Barsky D, Albala JS |title=Domain mapping of the Rad51 paralog protein complexes. |journal=Nucleic Acids Res. |volume=32 |issue= 1 |pages= 169–78 |year= 2004 |pmid= 14704354 |doi= 10.1093/nar/gkg925
*cite journal | author=Liu Y, Masson JY, Shah R, "et al." |title=RAD51C is required for Holliday junction processing in mammalian cells. |journal=Science |volume=303 |issue= 5655 |pages= 243–6 |year= 2004 |pmid= 14716019 |doi= 10.1126/science.1093037PBB_Controls
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