XRCC2

X-ray repair complementing defective repair in Chinese hamster cells 2, also known as XRCC2, is a human gene.cite web | title = Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7516| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.cite web | title = Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7516| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones NJ, Zhao Y, Siciliano MJ, Thompson LH |title=Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis. |journal=Genomics |volume=26 |issue= 3 |pages= 619–22 |year= 1995 |pmid= 7607692 |doi=
*cite journal | author=Thacker J, Tambini CE, Simpson PJ, "et al." |title=Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents. |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 113–20 |year= 1995 |pmid= 7711722 |doi=
*cite journal | author=Tambini CE, George AM, Rommens JM, "et al." |title=The XRCC2 DNA repair gene: identification of a positional candidate. |journal=Genomics |volume=41 |issue= 1 |pages= 84–92 |year= 1997 |pmid= 9126486 |doi= 10.1006/geno.1997.4636
*cite journal | author=Cartwright R, Tambini CE, Simpson PJ, Thacker J |title=The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. |journal=Nucleic Acids Res. |volume=26 |issue= 13 |pages= 3084–9 |year= 1998 |pmid= 9628903 |doi=
*cite journal | author=Liu N, Lamerdin JE, Tebbs RS, "et al." |title=XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. |journal=Mol. Cell |volume=1 |issue= 6 |pages= 783–93 |year= 1998 |pmid= 9660962 |doi=
*cite journal | author=Cui X, Brenneman M, Meyne J, "et al." |title=The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. |journal=Mutat. Res. |volume=434 |issue= 2 |pages= 75–88 |year= 1999 |pmid= 10422536 |doi=
*cite journal | author=Johnson RD, Liu N, Jasin M |title=Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. |journal=Nature |volume=401 |issue= 6751 |pages= 397–9 |year= 1999 |pmid= 10517641 |doi= 10.1038/43932
*cite journal | author=Schild D, Lio YC, Collins DW, "et al." |title=Evidence for simultaneous protein interactions between human Rad51 paralogs. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16443–9 |year= 2000 |pmid= 10749867 |doi= 10.1074/jbc.M001473200
*cite journal | author=Braybrooke JP, Spink KG, Thacker J, Hickson ID |title=The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 29100–6 |year= 2000 |pmid= 10871607 |doi= 10.1074/jbc.M002075200
*cite journal | author=O'Regan P, Wilson C, Townsend S, Thacker J |title=XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22148–53 |year= 2001 |pmid= 11301337 |doi= 10.1074/jbc.M102396200
*cite journal | author=Miller KA, Yoshikawa DM, McConnell IR, "et al." |title=RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8406–11 |year= 2002 |pmid= 11744692 |doi= 10.1074/jbc.M108306200
*cite journal | author=Masson JY, Tarsounas MC, Stasiak AZ, "et al." |title=Identification and purification of two distinct complexes containing the five RAD51 paralogs. |journal=Genes Dev. |volume=15 |issue= 24 |pages= 3296–307 |year= 2002 |pmid= 11751635 |doi= 10.1101/gad.947001
*cite journal | author=Kurumizaka H, Ikawa S, Nakada M, "et al." |title=Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14315–20 |year= 2002 |pmid= 11834724 |doi= 10.1074/jbc.M105719200
*cite journal | author=Wiese C, Collins DW, Albala JS, "et al." |title=Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1001–8 |year= 2002 |pmid= 11842112 |doi=
*cite journal | author=Liu N, Schild D, Thelen MP, Thompson LH |title=Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1009–15 |year= 2002 |pmid= 11842113 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Braybrooke JP, Li JL, Wu L, "et al." |title=Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48357–66 |year= 2004 |pmid= 12975363 |doi= 10.1074/jbc.M308838200
*cite journal | author=Mohindra A, Bolderson E, Stone J, "et al." |title=A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. |journal=Hum. Mol. Genet. |volume=13 |issue= 2 |pages= 203–12 |year= 2004 |pmid= 14645207 |doi= 10.1093/hmg/ddh022
*cite journal | author=Tarsounas M, Davies AA, West SC |title=RAD51 localization and activation following DNA damage. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=359 |issue= 1441 |pages= 87–93 |year= 2004 |pmid= 15065660 |doi= 10.1098/rstb.2003.1368
*cite journal | author=Hussain S, Wilson JB, Medhurst AL, "et al." |title=Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. |journal=Hum. Mol. Genet. |volume=13 |issue= 12 |pages= 1241–8 |year= 2004 |pmid= 15115758 |doi= 10.1093/hmg/ddh135

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