XRCC3

X-ray repair complementing defective repair in Chinese hamster cells 3, also known as XRCC3, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.cite web | title = Entrez Gene: XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7517| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kopecný J |title= [Rational approaches to the treatment of urinary incontinence (author's transl)] |journal=Ceskoslovenská gynekologie |volume=41 |issue= 6 |pages= 408–9 |year= 1976 |pmid= 975276 |doi=
*cite journal | author=Tebbs RS, Zhao Y, Tucker JD, "et al." |title=Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6354–8 |year= 1995 |pmid= 7603995 |doi=
*cite journal | author=Price EA, Bourne SL, Radbourne R, "et al." |title=Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 4 |pages= 237–47 |year= 1998 |pmid= 9542526 |doi=
*cite journal | author=Liu N, Lamerdin JE, Tebbs RS, "et al." |title=XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. |journal=Mol. Cell |volume=1 |issue= 6 |pages= 783–93 |year= 1998 |pmid= 9660962 |doi=
*cite journal | author=Pierce AJ, Johnson RD, Thompson LH, Jasin M |title=XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. |journal=Genes Dev. |volume=13 |issue= 20 |pages= 2633–8 |year= 1999 |pmid= 10541549 |doi=
*cite journal | author=Winsey SL, Haldar NA, Marsh HP, "et al." |title=A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. |journal=Cancer Res. |volume=60 |issue= 20 |pages= 5612–6 |year= 2000 |pmid= 11059748 |doi=
*cite journal | author=Kurumizaka H, Ikawa S, Nakada M, "et al." |title=Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 10 |pages= 5538–43 |year= 2001 |pmid= 11331762 |doi= 10.1073/pnas.091603098
*cite journal | author=Masson JY, Stasiak AZ, Stasiak A, "et al." |title=Complex formation by the human RAD51C and XRCC3 recombination repair proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8440–6 |year= 2001 |pmid= 11459987 |doi= 10.1073/pnas.111005698
*cite journal | author=Miller KA, Yoshikawa DM, McConnell IR, "et al." |title=RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8406–11 |year= 2002 |pmid= 11744692 |doi= 10.1074/jbc.M108306200
*cite journal | author=Liu N, Schild D, Thelen MP, Thompson LH |title=Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. |journal=Nucleic Acids Res. |volume=30 |issue= 4 |pages= 1009–15 |year= 2002 |pmid= 11842113 |doi=
*cite journal | author=Shen H, Sturgis EM, Dahlstrom KR, "et al." |title=A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis. |journal=Int. J. Cancer |volume=99 |issue= 6 |pages= 869–72 |year= 2002 |pmid= 12115490 |doi= 10.1002/ijc.10413
*cite journal | author=Duan Z, Shen H, Lee JE, "et al." |title=DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=11 |issue= 10 Pt 1 |pages= 1142–3 |year= 2002 |pmid= 12376526 |doi=
*cite journal | author=Seedhouse C, Bainton R, Lewis M, "et al." |title=The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. |journal=Blood |volume=100 |issue= 10 |pages= 3761–6 |year= 2003 |pmid= 12393447 |doi= 10.1182/blood-2002-04-1152
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Smith TR, Miller MS, Lohman K, "et al." |title=Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. |journal=Cancer Lett. |volume=190 |issue= 2 |pages= 183–90 |year= 2003 |pmid= 12565173 |doi=
*cite journal | author=Jacobsen NR, Nexø BA, Olsen A, "et al." |title=No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=12 |issue= 6 |pages= 584–5 |year= 2004 |pmid= 12815008 |doi=
*cite journal | author=Zhu G, Duffy DL, Turner DR, "et al." |title=Linkage and association analysis of radiation damage repair genes XRCC3 and XRCC5 with nevus density in adolescent twins. |journal=Twin research : the official journal of the International Society for Twin Studies |volume=6 |issue= 4 |pages= 315–21 |year= 2005 |pmid= 14511439 |doi= 10.1375/136905203322296683
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bertram CG, Gaut RM, Barrett JH, "et al." |title=An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 429–32 |year= 2004 |pmid= 15009726 |doi= 10.1046/j.0022-202X.2003.12541.x
*cite journal | author=Tarsounas M, Davies AA, West SC |title=RAD51 localization and activation following DNA damage. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=359 |issue= 1441 |pages= 87–93 |year= 2004 |pmid= 15065660 |doi= 10.1098/rstb.2003.1368

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