XRCC1

XRCC1 is a DNA repair protein.

It complexes with DNA ligase III.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [cite web | title = Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7515| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hung RJ, Hall J, Brennan P, Boffetta P |title=Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. |journal=Am. J. Epidemiol. |volume=162 |issue= 10 |pages= 925–42 |year= 2006 |pmid= 16221808 |doi= 10.1093/aje/kwi318
*cite journal | author=Thompson LH, Brookman KW, Jones NJ, "et al." |title=Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6160–71 |year= 1991 |pmid= 2247054 |doi=
*cite journal | author=Thompson LH, Bachinski LL, Stallings RL, "et al." |title=Complementation of repair gene mutations on the hemizygous chromosome 9 in CHO: a third repair gene on human chromosome 19. |journal=Genomics |volume=5 |issue= 4 |pages= 670–9 |year= 1990 |pmid= 2591959 |doi=
*cite journal | author=Gyapay G, Morissette J, Vignal A, "et al." |title=The 1993-94 Généthon human genetic linkage map. |journal=Nat. Genet. |volume=7 |issue= 2 Spec No |pages= 246–339 |year= 1994 |pmid= 7545953 |doi= 10.1038/ng0694supp-246
*cite journal | author=Wei Q, Xu X, Cheng L, "et al." |title=Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR. |journal=Cancer Res. |volume=55 |issue= 21 |pages= 5025–9 |year= 1995 |pmid= 7585546 |doi=
*cite journal | author=Lamerdin JE, Montgomery MA, Stilwagen SA, "et al." |title=Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. |journal=Genomics |volume=25 |issue= 2 |pages= 547–54 |year= 1995 |pmid= 7789989 |doi=
*cite journal | author=Caldecott KW, McKeown CK, Tucker JD, "et al." |title=An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. |journal=Mol. Cell. Biol. |volume=14 |issue= 1 |pages= 68–76 |year= 1994 |pmid= 8264637 |doi=
*cite journal | author=Trask B, Fertitta A, Christensen M, "et al." |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=
*cite journal | author=Kubota Y, Nash RA, Klungland A, "et al." |title=Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. |journal=EMBO J. |volume=15 |issue= 23 |pages= 6662–70 |year= 1997 |pmid= 8978692 |doi=
*cite journal | author=Nash RA, Caldecott KW, Barnes DE, Lindahl T |title=XRCC1 protein interacts with one of two distinct forms of DNA ligase III. |journal=Biochemistry |volume=36 |issue= 17 |pages= 5207–11 |year= 1997 |pmid= 9136882 |doi= 10.1021/bi962281m
*cite journal | author=Shen MR, Jones IM, Mohrenweiser H |title=Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. |journal=Cancer Res. |volume=58 |issue= 4 |pages= 604–8 |year= 1998 |pmid= 9485007 |doi=
*cite journal | author=Price EA, Bourne SL, Radbourne R, "et al." |title=Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity. |journal=Somat. Cell Mol. Genet. |volume=23 |issue= 4 |pages= 237–47 |year= 1998 |pmid= 9542526 |doi=
*cite journal | author=Masson M, Niedergang C, Schreiber V, "et al." |title=XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3563–71 |year= 1998 |pmid= 9584196 |doi=
*cite journal | author=Taylor RM, Wickstead B, Cronin S, Caldecott KW |title=Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1. |journal=Curr. Biol. |volume=8 |issue= 15 |pages= 877–80 |year= 1998 |pmid= 9705932 |doi=
*cite journal | author=Zhou ZQ, Walter CA |title=Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 1 |pages= 23–39 |year= 1998 |pmid= 9776979 |doi=
*cite journal | author=Taylor RM, Moore DJ, Whitehouse J, "et al." |title=A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 735–40 |year= 2000 |pmid= 10611252 |doi=
*cite journal | author=Marintchev A, Robertson A, Dimitriadis EK, "et al." |title=Domain specific interaction in the XRCC1-DNA polymerase beta complex. |journal=Nucleic Acids Res. |volume=28 |issue= 10 |pages= 2049–59 |year= 2000 |pmid= 10773072 |doi=
*cite journal | author=Duell EJ, Wiencke JK, Cheng TJ, "et al." |title=Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. |journal=Carcinogenesis |volume=21 |issue= 5 |pages= 965–71 |year= 2000 |pmid= 10783319 |doi=
*cite journal | author=Whitehouse CJ, Taylor RM, Thistlethwaite A, "et al." |title=XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. |journal=Cell |volume=104 |issue= 1 |pages= 107–17 |year= 2001 |pmid= 11163244 |doi=
*cite journal | author=Dulic A, Bates PA, Zhang X, "et al." |title=BRCT domain interactions in the heterodimeric DNA repair protein XRCC1-DNA ligase III. |journal=Biochemistry |volume=40 |issue= 20 |pages= 5906–13 |year= 2001 |pmid= 11352725 |doi=

External links

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