RNPS1

RNA binding protein S1, serine-rich domain, also known as RNPS1, is a human gene.cite web | title = Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10921| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.cite web | title = Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10921| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Badolato J, Gardiner E, Morrison N, Eisman J |title=Identification and characterisation of a novel human RNA-binding protein. |journal=Gene |volume=166 |issue= 2 |pages= 323–7 |year= 1996 |pmid= 8543184 |doi=
*cite journal | author=Burn TC, Connors TD, Van Raay TJ, "et al." |title=Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. |journal=Genome Res. |volume=6 |issue= 6 |pages= 525–37 |year= 1996 |pmid= 8828041 |doi=
*cite journal | author=Loyer P, Trembley JH, Lahti JM, Kidd VJ |title=The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo. |journal=J. Cell. Sci. |volume=111 ( Pt 11) |issue= |pages= 1495–506 |year= 1998 |pmid= 9580558 |doi=
*cite journal | author=Wilson KF, Fortes P, Singh US, "et al." |title=The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4166–73 |year= 1999 |pmid= 9933612 |doi=
*cite journal | author=Mayeda A, Badolato J, Kobayashi R, "et al." |title=Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. |journal=EMBO J. |volume=18 |issue= 16 |pages= 4560–70 |year= 1999 |pmid= 10449421 |doi= 10.1093/emboj/18.16.4560
*cite journal | author=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860–9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860
*cite journal | author=Harada K, Yamada A, Yang D, "et al." |title=Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. |journal=Int. J. Cancer |volume=93 |issue= 5 |pages= 623–8 |year= 2001 |pmid= 11477570 |doi=
*cite journal | author=Kim VN, Kataoka N, Dreyfuss G |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. |journal=Science |volume=293 |issue= 5536 |pages= 1832–6 |year= 2001 |pmid= 11546873 |doi= 10.1126/science.1062829
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786
*cite journal | author=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536–45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=McCracken S, Longman D, Johnstone IL, "et al." |title=An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44153–60 |year= 2004 |pmid= 12944400 |doi= 10.1074/jbc.M306856200
*cite journal | author=Li C, Lin RI, Lai MC, "et al." |title=Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7363–76 |year= 2003 |pmid= 14517304 |doi=
*cite journal | author=Kataoka N, Dreyfuss G |title=A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7009–13 |year= 2004 |pmid= 14625303 |doi= 10.1074/jbc.M307692200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sakashita E, Tatsumi S, Werner D, "et al." |title=Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1174–87 |year= 2004 |pmid= 14729963 |doi=
*cite journal | author=Nott A, Le Hir H, Moore MJ |title=Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. |journal=Genes Dev. |volume=18 |issue= 2 |pages= 210–22 |year= 2004 |pmid= 14752011 |doi= 10.1101/gad.1163204
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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