RBM8A

RNA binding motif protein 8A, also known as RBM8A, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.cite web | title = Entrez Gene: RBM8A RNA binding motif protein 8A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9939| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wilson KF, Fortes P, Singh US, "et al." |title=The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4166–73 |year= 1999 |pmid= 9933612 |doi=
*cite journal | author=Zhao XF, Nowak NJ, Shows TB, Aplan PD |title=MAGOH interacts with a novel RNA-binding protein. |journal=Genomics |volume=63 |issue= 1 |pages= 145–8 |year= 2000 |pmid= 10662555 |doi= 10.1006/geno.1999.6064
*cite journal | author=Conklin DC, Rixon MW, Kuestner RE, "et al." |title=Cloning and gene expression of a novel human ribonucleoprotein. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 2-3 |pages= 465–9 |year= 2000 |pmid= 11004516 |doi=
*cite journal | author=Salicioni AM, Xi M, Vanderveer LA, "et al." |title=Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. |journal=Genomics |volume=69 |issue= 1 |pages= 54–62 |year= 2001 |pmid= 11013075 |doi= 10.1006/geno.2000.6315
*cite journal | author=Kataoka N, Yong J, Kim VN, "et al." |title=Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. |journal=Mol. Cell |volume=6 |issue= 3 |pages= 673–82 |year= 2000 |pmid= 11030346 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860–9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860
*cite journal | author=Mingot JM, Kostka S, Kraft R, "et al." |title=Importin 13: a novel mediator of nuclear import and export. |journal=EMBO J. |volume=20 |issue= 14 |pages= 3685–94 |year= 2001 |pmid= 11447110 |doi= 10.1093/emboj/20.14.3685
*cite journal | author=Kim VN, Kataoka N, Dreyfuss G |title=Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex. |journal=Science |volume=293 |issue= 5536 |pages= 1832–6 |year= 2001 |pmid= 11546873 |doi= 10.1126/science.1062829
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786
*cite journal | author=Hachet O, Ephrussi A |title=Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport. |journal=Curr. Biol. |volume=11 |issue= 21 |pages= 1666–74 |year= 2002 |pmid= 11696323 |doi=
*cite journal | author=Faurholm B, Millar RP, Katz AA |title=The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. |journal=Genomics |volume=78 |issue= 1-2 |pages= 15–8 |year= 2002 |pmid= 11707068 |doi= 10.1006/geno.2001.6650
*cite journal | author=Kataoka N, Diem MD, Kim VN, "et al." |title=Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. |journal=EMBO J. |volume=20 |issue= 22 |pages= 6424–33 |year= 2002 |pmid= 11707413 |doi= 10.1093/emboj/20.22.6424
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Okubo K, Mitani H, Naruse K, "et al." |title=Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 327–31 |year= 2002 |pmid= 12054603 |doi= 10.1016/S0006-291X(02)00161-4
*cite journal | author=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536–45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gehring NH, Neu-Yilik G, Schell T, "et al." |title=Y14 and hUpf3b form an NMD-activating complex. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 939–49 |year= 2003 |pmid= 12718880 |doi=
*cite journal | author=Fribourg S, Gatfield D, Izaurralde E, Conti E |title=A novel mode of RBD-protein recognition in the Y14-Mago complex. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 433–9 |year= 2003 |pmid= 12730685 |doi= 10.1038/nsb926
*cite journal | author=Lau CK, Diem MD, Dreyfuss G, Van Duyne GD |title=Structure of the Y14-Magoh core of the exon junction complex. |journal=Curr. Biol. |volume=13 |issue= 11 |pages= 933–41 |year= 2004 |pmid= 12781131 |doi=

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